Polygenic Score (PGS) ID: PGS001774

Predicted Trait
Reported Trait Parkinson's disease
Mapped Trait(s) Parkinson disease (MONDO_0005180)
Released in PGS Catalog: Nov. 25, 2021
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Score Details

Score Construction
PGS Name PRS12_PD
Development Method
Name Variants associated with Parkinson's disease
Parameters NR
Variants
Original Genome Build NR
Number of Variants 12
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000254
Citation (link to publication) Chairta PP et al. Genes (Basel) (2021)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
158,108 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST001126
Europe PMC: 21738487
 33,050 individuals European 23andMe
GWAS Catalog: GCST000855
Europe PMC: 21044948
 6,880 individuals European NR
GWAS Catalog: GCST000528
Europe PMC: 19915575
 5,691 individuals European NR
GWAS Catalog: GCST000567
Europe PMC: 20070850
 3,497 individuals European NR
GWAS Catalog: GCST002544
Europe PMC: 25064009
 108,990 individuals European 7 cohorts
  • 23andMe
  • ,Ash-Jewish
  • ,CHARGE
  • ,HIHG
  • ,IPDGC
  • ,NGRC
  • ,PGPD

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM009233 PSS007662|
European Ancestry|
699 individuals
 PGP000254 |
Chairta PP et al. Genes (Basel) (2021)
 Reported Trait: Parkinson's disease OR: 1.39 [1.06, 1.84] AUROC: 0.55 — — Prior to imputation of missing data
PPM009234 PSS007662|
European Ancestry|
699 individuals
 PGP000254 |
Chairta PP et al. Genes (Basel) (2021)
 Reported Trait: Parkinson's disease — AUROC: 0.79 [0.75, 0.83] — Age, gender, head injury, family history of Parkinson's disease, depression, smoking (current or ever), body mass index Prior to imputation of missing data
PPM009235 PSS007662|
European Ancestry|
699 individuals
 PGP000254 |
Chairta PP et al. Genes (Basel) (2021)
 Reported Trait: Parkinson's disease OR: 1.39 [1.06, 1.83] AUROC: 0.55 — — Following imputation of missing data
PPM009236 PSS007662|
European Ancestry|
699 individuals
 PGP000254 |
Chairta PP et al. Genes (Basel) (2021)
 Reported Trait: Parkinson's disease — AUROC: 0.8 [0.77, 0.84] — Age, gender, head injury, family history of Parkinson's disease, depression, smoking (current or ever), body mass index Following imputation of missing data

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007662 Cases were individuals with Parkinson's disease (PD). All cases were recruited in the study after a clinical diagnosis of PD. —
[
  • 235 cases
  • , 464 controls
]
,
51.36 % Male samples
 — European — NR —