Polygenic Score (PGS) ID: PGS001827

Predicted Trait
Reported Trait Dementias
Mapped Trait(s) dementia (MONDO_0001627)
Additional Trait Information psychiatric disorders
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-PLR_290.1
Development Method
Name Penalized regression (bigstatsr)
Parameters HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 33
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
391,124 individuals European UK (+ Ireland) UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM009511 PSS008625|
European Ancestry|
6,562 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Dementias Partial Correlation (partial-r): 0.0324 [0.0081, 0.0565] sex, age, birth date, deprivation index, 16 PCs
PPM009512 PSS008399|
Greater Middle Eastern Ancestry|
1,186 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Dementias Partial Correlation (partial-r): 0.0695 [0.0122, 0.1264] sex, age, birth date, deprivation index, 16 PCs
PPM009509 PSS009297|
European Ancestry|
19,618 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Dementias Partial Correlation (partial-r): 0.0455 [0.0315, 0.0595] sex, age, birth date, deprivation index, 16 PCs
PPM009510 PSS009071|
European Ancestry|
4,070 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Dementias Partial Correlation (partial-r): 0.025 [-0.0058, 0.0558] sex, age, birth date, deprivation index, 16 PCs
PPM009513 PSS008179|
South Asian Ancestry|
6,222 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Dementias Partial Correlation (partial-r): 0.046 [0.0211, 0.0708] sex, age, birth date, deprivation index, 16 PCs
PPM009514 PSS007964|
East Asian Ancestry|
1,802 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Dementias Partial Correlation (partial-r): 0.0477 [0.0013, 0.094] sex, age, birth date, deprivation index, 16 PCs
PPM009515 PSS007745|
African Ancestry|
2,441 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Dementias Partial Correlation (partial-r): 0.0445 [0.0047, 0.0842] sex, age, birth date, deprivation index, 16 PCs
PPM009516 PSS008849|
African Ancestry|
3,852 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Dementias Partial Correlation (partial-r): 0.0522 [0.0206, 0.0837] sex, age, birth date, deprivation index, 16 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008399 1,186 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS009071 4,070 individuals European Poland (NE Europe) UKB
PSS008625 6,562 individuals European Italy (South Europe) UKB
PSS009297 19,618 individuals European UK (+ Ireland) UKB
PSS008179 6,222 individuals South Asian India (South Asia) UKB
PSS008849 3,852 individuals African unspecified Nigeria (West Africa) UKB
PSS007964 1,802 individuals East Asian China (East Asia) UKB
PSS007745 2,441 individuals African American or Afro-Caribbean Carribean UKB