Polygenic Score (PGS) ID: PGS001848

Predicted Trait
Reported Trait Nasal polyps
Mapped Trait(s) Nasal polyposis (HP_0100582)
Additional Trait Information respiratory
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-PLR_471
Development Method
Name Penalized regression (bigstatsr)
Parameters HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 1,783
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
391,124 individuals European UK (+ Ireland) UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM009674 PSS009323|
European Ancestry|
19,106 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Nasal polyps Partial Correlation (partial-r): 0.0469 [0.0327, 0.0611] sex, age, birth date, deprivation index, 16 PCs
PPM009675 PSS009097|
European Ancestry|
3,952 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Nasal polyps Partial Correlation (partial-r): 0.0653 [0.0341, 0.0963] sex, age, birth date, deprivation index, 16 PCs
PPM009676 PSS008651|
European Ancestry|
6,357 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Nasal polyps Partial Correlation (partial-r): 0.0455 [0.0209, 0.07] sex, age, birth date, deprivation index, 16 PCs
PPM009677 PSS008425|
Greater Middle Eastern Ancestry|
1,114 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Nasal polyps Partial Correlation (partial-r): 0.0094 [-0.0499, 0.0686] sex, age, birth date, deprivation index, 16 PCs
PPM009679 PSS007987|
East Asian Ancestry|
1,740 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Nasal polyps Partial Correlation (partial-r): 0.0006 [-0.0467, 0.0478] sex, age, birth date, deprivation index, 16 PCs
PPM009680 PSS007770|
African Ancestry|
2,365 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Nasal polyps Partial Correlation (partial-r): -0.011 [-0.0514, 0.0295] sex, age, birth date, deprivation index, 16 PCs
PPM009681 PSS008874|
African Ancestry|
3,758 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Nasal polyps Partial Correlation (partial-r): 0.0034 [-0.0286, 0.0355] sex, age, birth date, deprivation index, 16 PCs
PPM009678 PSS008205|
South Asian Ancestry|
6,007 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Nasal polyps Partial Correlation (partial-r): 0.0287 [0.0034, 0.054] sex, age, birth date, deprivation index, 16 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008425 1,114 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS009097 3,952 individuals European Poland (NE Europe) UKB
PSS008651 6,357 individuals European Italy (South Europe) UKB
PSS009323 19,106 individuals European UK (+ Ireland) UKB
PSS008874 3,758 individuals African unspecified Nigeria (West Africa) UKB
PSS008205 6,007 individuals South Asian India (South Asia) UKB
PSS007987 1,740 individuals East Asian China (East Asia) UKB
PSS007770 2,365 individuals African American or Afro-Caribbean Carribean UKB