Polygenic Score (PGS) ID: PGS001849

Predicted Trait
Reported Trait Asthma
Mapped Trait(s) asthma (MONDO_0004979)
Additional Trait Information respiratory
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-PLR_495
Development Method
Name Penalized regression (bigstatsr)
Parameters HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 22,679
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM009682 PSS009324|
European Ancestry|
19,551 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Asthma — — Partial Correlation (partial-r): 0.1135 [0.0997, 0.1274] sex, age, birth date, deprivation index, 16 PCs —
PPM009683 PSS009098|
European Ancestry|
4,078 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Asthma — — Partial Correlation (partial-r): 0.0477 [0.017, 0.0784] sex, age, birth date, deprivation index, 16 PCs —
PPM009684 PSS008652|
European Ancestry|
6,537 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Asthma — — Partial Correlation (partial-r): 0.0847 [0.0606, 0.1088] sex, age, birth date, deprivation index, 16 PCs —
PPM009685 PSS008426|
Greater Middle Eastern Ancestry|
1,183 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Asthma — — Partial Correlation (partial-r): 0.0818 [0.0244, 0.1386] sex, age, birth date, deprivation index, 16 PCs —
PPM009686 PSS008206|
South Asian Ancestry|
6,270 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Asthma — — Partial Correlation (partial-r): 0.098 [0.0734, 0.1225] sex, age, birth date, deprivation index, 16 PCs —
PPM009687 PSS007988|
East Asian Ancestry|
1,803 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Asthma — — Partial Correlation (partial-r): 0.0312 [-0.0153, 0.0775] sex, age, birth date, deprivation index, 16 PCs —
PPM009688 PSS007771|
African Ancestry|
2,462 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Asthma — — Partial Correlation (partial-r): 0.0528 [0.0132, 0.0923] sex, age, birth date, deprivation index, 16 PCs —
PPM009689 PSS008875|
African Ancestry|
3,892 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Asthma — — Partial Correlation (partial-r): 0.0161 [-0.0154, 0.0476] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009098 — — 4,078 individuals — European Poland (NE Europe) UKB —
PSS008426 — — 1,183 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009324 — — 19,551 individuals — European UK (+ Ireland) UKB —
PSS008652 — — 6,537 individuals — European Italy (South Europe) UKB —
PSS008206 — — 6,270 individuals — South Asian India (South Asia) UKB —
PSS008875 — — 3,892 individuals — African unspecified Nigeria (West Africa) UKB —
PSS007988 — — 1,803 individuals — East Asian China (East Asia) UKB —
PSS007771 — — 2,462 individuals — African American or Afro-Caribbean Carribean UKB —