Polygenic Score (PGS) ID: PGS001857

Predicted Trait
Reported Trait Diverticulosis
Mapped Trait(s) Colonic diverticula (HP_0002253)
Additional Trait Information digestive
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-PLR_562.1
Development Method
Name Penalized regression (bigstatsr)
Parameters HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 23,800
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM009745 PSS009332|
European Ancestry|
17,645 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Diverticulosis — — Partial Correlation (partial-r): 0.0896 [0.0749, 0.1042] sex, age, birth date, deprivation index, 16 PCs —
PPM009746 PSS009106|
European Ancestry|
3,723 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Diverticulosis — — Partial Correlation (partial-r): 0.1026 [0.0706, 0.1343] sex, age, birth date, deprivation index, 16 PCs —
PPM009747 PSS008660|
European Ancestry|
5,841 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Diverticulosis — — Partial Correlation (partial-r): 0.0849 [0.0593, 0.1104] sex, age, birth date, deprivation index, 16 PCs —
PPM009748 PSS008434|
Greater Middle Eastern Ancestry|
1,057 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Diverticulosis — — Partial Correlation (partial-r): 0.1413 [0.0811, 0.2004] sex, age, birth date, deprivation index, 16 PCs —
PPM009749 PSS008214|
South Asian Ancestry|
5,515 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Diverticulosis — — Partial Correlation (partial-r): 0.068 [0.0416, 0.0942] sex, age, birth date, deprivation index, 16 PCs —
PPM009750 PSS007995|
East Asian Ancestry|
1,638 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Diverticulosis — — Partial Correlation (partial-r): -0.0033 [-0.052, 0.0454] sex, age, birth date, deprivation index, 16 PCs —
PPM009751 PSS007779|
African Ancestry|
2,211 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Diverticulosis — — Partial Correlation (partial-r): 0.0777 [0.0359, 0.1192] sex, age, birth date, deprivation index, 16 PCs —
PPM009752 PSS008883|
African Ancestry|
3,605 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Diverticulosis — — Partial Correlation (partial-r): 0.0342 [0.0015, 0.0669] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009106 — — 3,723 individuals — European Poland (NE Europe) UKB —
PSS008434 — — 1,057 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009332 — — 17,645 individuals — European UK (+ Ireland) UKB —
PSS008660 — — 5,841 individuals — European Italy (South Europe) UKB —
PSS008214 — — 5,515 individuals — South Asian India (South Asia) UKB —
PSS008883 — — 3,605 individuals — African unspecified Nigeria (West Africa) UKB —
PSS007995 — — 1,638 individuals — East Asian China (East Asia) UKB —
PSS007779 — — 2,211 individuals — African American or Afro-Caribbean Carribean UKB —