Polygenic Score (PGS) ID: PGS001886

Predicted Trait
Reported Trait Albumin
Mapped Trait(s) serum albumin measurement (EFO_0004535)
Additional Trait Information biological measures
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-PLR_albumin
Development Method
Name Penalized regression (bigstatsr)
Parameters HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 60,423
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
391,124 individuals European UK (+ Ireland) UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM009972 PSS009382|
European Ancestry|
17,457 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Albumin Partial Correlation (partial-r): 0.2949 [0.2813, 0.3084] sex, age, birth date, deprivation index, 16 PCs
PPM009973 PSS009156|
European Ancestry|
3,593 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Albumin Partial Correlation (partial-r): 0.2758 [0.2452, 0.3058] sex, age, birth date, deprivation index, 16 PCs
PPM009974 PSS008710|
European Ancestry|
5,803 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Albumin Partial Correlation (partial-r): 0.2722 [0.2482, 0.2959] sex, age, birth date, deprivation index, 16 PCs
PPM009975 PSS008484|
Greater Middle Eastern Ancestry|
1,036 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Albumin Partial Correlation (partial-r): 0.2704 [0.2124, 0.3264] sex, age, birth date, deprivation index, 16 PCs
PPM009976 PSS008262|
South Asian Ancestry|
5,478 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Albumin Partial Correlation (partial-r): 0.2714 [0.2467, 0.2958] sex, age, birth date, deprivation index, 16 PCs
PPM009977 PSS008040|
East Asian Ancestry|
1,560 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Albumin Partial Correlation (partial-r): 0.226 [0.178, 0.2729] sex, age, birth date, deprivation index, 16 PCs
PPM009978 PSS007826|
African Ancestry|
2,159 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Albumin Partial Correlation (partial-r): 0.1475 [0.1058, 0.1887] sex, age, birth date, deprivation index, 16 PCs
PPM009979 PSS008930|
African Ancestry|
3,401 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Albumin Partial Correlation (partial-r): 0.1407 [0.1075, 0.1736] sex, age, birth date, deprivation index, 16 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009156 3,593 individuals European Poland (NE Europe) UKB
PSS008484 1,036 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS009382 17,457 individuals European UK (+ Ireland) UKB
PSS008710 5,803 individuals European Italy (South Europe) UKB
PSS008262 5,478 individuals South Asian India (South Asia) UKB
PSS008040 1,560 individuals East Asian China (East Asia) UKB
PSS007826 2,159 individuals African American or Afro-Caribbean Carribean UKB
PSS008930 3,401 individuals African unspecified Nigeria (West Africa) UKB