Polygenic Score (PGS) ID: PGS001887

Predicted Trait
Reported Trait Ankle spacing width
Mapped Trait(s) anthropometric measurement (EFO_0004302)
Additional Trait Information physical measures
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-PLR_ankle_spacing
Development Method
Name Penalized regression (bigstatsr)
Parameters HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 89,827
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
391,124 individuals European UK (+ Ireland) UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM009981 PSS009157|
European Ancestry|
2,149 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ankle spacing width Partial Correlation (partial-r): 0.402 [0.3658, 0.437] sex, age, birth date, deprivation index, 16 PCs
PPM009982 PSS008711|
European Ancestry|
3,469 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ankle spacing width Partial Correlation (partial-r): 0.3944 [0.3659, 0.4222] sex, age, birth date, deprivation index, 16 PCs
PPM009983 PSS008485|
Greater Middle Eastern Ancestry|
507 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ankle spacing width Partial Correlation (partial-r): 0.3841 [0.3057, 0.4574] sex, age, birth date, deprivation index, 16 PCs
PPM009984 PSS008263|
South Asian Ancestry|
1,985 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ankle spacing width Partial Correlation (partial-r): 0.3675 [0.3286, 0.4051] sex, age, birth date, deprivation index, 16 PCs
PPM009985 PSS008041|
East Asian Ancestry|
819 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ankle spacing width Partial Correlation (partial-r): 0.3258 [0.2623, 0.3864] sex, age, birth date, deprivation index, 16 PCs
PPM009986 PSS007827|
African Ancestry|
801 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ankle spacing width Partial Correlation (partial-r): 0.2218 [0.1541, 0.2875] sex, age, birth date, deprivation index, 16 PCs
PPM009987 PSS008931|
African Ancestry|
1,421 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ankle spacing width Partial Correlation (partial-r): 0.1388 [0.0871, 0.1898] sex, age, birth date, deprivation index, 16 PCs
PPM009980 PSS009383|
European Ancestry|
11,502 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ankle spacing width Partial Correlation (partial-r): 0.4249 [0.4098, 0.4398] sex, age, birth date, deprivation index, 16 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008485 507 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS009157 2,149 individuals European Poland (NE Europe) UKB
PSS008711 3,469 individuals European Italy (South Europe) UKB
PSS008263 1,985 individuals South Asian India (South Asia) UKB
PSS008041 819 individuals East Asian China (East Asia) UKB
PSS009383 11,502 individuals European UK (+ Ireland) UKB
PSS007827 801 individuals African American or Afro-Caribbean Carribean UKB
PSS008931 1,421 individuals African unspecified Nigeria (West Africa) UKB