Polygenic Score (PGS) ID: PGS001903

Predicted Trait
Reported Trait PP interval
Mapped Trait(s) electrocardiography (EFO_0004327)
Additional Trait Information physical measures
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-PLR_ECG_PP_interval
Development Method
Name Penalized regression (bigstatsr)
Parameters HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 4,368
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
391,124 individuals European UK (+ Ireland) UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM010108 PSS009137|
European Ancestry|
191 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: PP interval Partial Correlation (partial-r): 0.1015 [-0.0493, 0.2478] sex, age, birth date, deprivation index, 16 PCs
PPM010109 PSS008691|
European Ancestry|
225 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: PP interval Partial Correlation (partial-r): 0.1429 [0.006, 0.2745] sex, age, birth date, deprivation index, 16 PCs
PPM010110 PSS008465|
Greater Middle Eastern Ancestry|
25 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: PP interval Partial Correlation (partial-r): -0.3367 [-0.9398, 0.7761] sex, age, birth date, deprivation index, 16 PCs
PPM010111 PSS008245|
South Asian Ancestry|
165 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: PP interval Partial Correlation (partial-r): 0.0817 [-0.0824, 0.2415] sex, age, birth date, deprivation index, 16 PCs
PPM010113 PSS007809|
African Ancestry|
49 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: PP interval Partial Correlation (partial-r): 0.0201 [-0.349, 0.3838] sex, age, birth date, deprivation index, 16 PCs
PPM010114 PSS008913|
African Ancestry|
61 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: PP interval Partial Correlation (partial-r): 0.2346 [-0.0787, 0.5057] sex, age, birth date, deprivation index, 16 PCs
PPM010107 PSS009363|
European Ancestry|
1,036 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: PP interval Partial Correlation (partial-r): 0.1051 [0.0439, 0.1655] sex, age, birth date, deprivation index, 16 PCs
PPM010112 PSS008023|
East Asian Ancestry|
73 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: PP interval Partial Correlation (partial-r): 0.144 [-0.1314, 0.3987] sex, age, birth date, deprivation index, 16 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008465 25 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS009137 191 individuals European Poland (NE Europe) UKB
PSS008691 225 individuals European Italy (South Europe) UKB
PSS008913 61 individuals African unspecified Nigeria (West Africa) UKB
PSS008245 165 individuals South Asian India (South Asia) UKB
PSS009363 1,036 individuals European UK (+ Ireland) UKB
PSS008023 73 individuals East Asian China (East Asia) UKB
PSS007809 49 individuals African American or Afro-Caribbean Carribean UKB