Polygenic Score (PGS) ID: PGS001905

Predicted Trait
Reported Trait QT interval
Mapped Trait(s) QT interval (EFO_0004682)
Additional Trait Information physical measures
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-PLR_ECG_QT_interval
Development Method
Name Penalized regression (bigstatsr)
Parameters HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 2,300
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM010124 PSS009141|
European Ancestry|
193 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: QT interval — — Partial Correlation (partial-r): 0.1764 [0.0279, 0.3172] sex, age, birth date, deprivation index, 16 PCs —
PPM010125 PSS008695|
European Ancestry|
226 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: QT interval — — Partial Correlation (partial-r): 0.2353 [0.1019, 0.3604] sex, age, birth date, deprivation index, 16 PCs —
PPM010126 PSS008469|
Greater Middle Eastern Ancestry|
26 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: QT interval — — Partial Correlation (partial-r): -0.1488 [-0.8569, 0.7538] sex, age, birth date, deprivation index, 16 PCs —
PPM010127 PSS008249|
South Asian Ancestry|
165 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: QT interval — — Partial Correlation (partial-r): -0.0176 [-0.18, 0.1459] sex, age, birth date, deprivation index, 16 PCs —
PPM010128 PSS008027|
East Asian Ancestry|
73 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: QT interval — — Partial Correlation (partial-r): 0.325 [0.06, 0.5472] sex, age, birth date, deprivation index, 16 PCs —
PPM010129 PSS007813|
African Ancestry|
49 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: QT interval — — Partial Correlation (partial-r): -0.034 [-0.3956, 0.3367] sex, age, birth date, deprivation index, 16 PCs —
PPM010130 PSS008917|
African Ancestry|
61 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: QT interval — — Partial Correlation (partial-r): 0.1053 [-0.2091, 0.4] sex, age, birth date, deprivation index, 16 PCs —
PPM010123 PSS009367|
European Ancestry|
1,042 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: QT interval — — Partial Correlation (partial-r): 0.1488 [0.0883, 0.2082] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007813 — — 49 individuals — African American or Afro-Caribbean Carribean UKB —
PSS008469 — — 26 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009141 — — 193 individuals — European Poland (NE Europe) UKB —
PSS008695 — — 226 individuals — European Italy (South Europe) UKB —
PSS008917 — — 61 individuals — African unspecified Nigeria (West Africa) UKB —
PSS008249 — — 165 individuals — South Asian India (South Asia) UKB —
PSS009367 — — 1,042 individuals — European UK (+ Ireland) UKB —
PSS008027 — — 73 individuals — East Asian China (East Asia) UKB —