Polygenic Score (PGS) ID: PGS001907

Predicted Trait
Reported Trait RR interval
Mapped Trait(s) RR interval (EFO_0004831)
Additional Trait Information physical measures
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-PLR_ECG_RR_interval
Development Method
Name Penalized regression (bigstatsr)
Parameters HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 1,964
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
391,124 individuals European UK (+ Ireland) UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM010139 PSS009368|
European Ancestry|
1,042 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: RR interval Partial Correlation (partial-r): 0.065 [0.0037, 0.1258] sex, age, birth date, deprivation index, 16 PCs
PPM010140 PSS009142|
European Ancestry|
193 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: RR interval Partial Correlation (partial-r): 0.0882 [-0.0618, 0.2343] sex, age, birth date, deprivation index, 16 PCs
PPM010141 PSS008696|
European Ancestry|
226 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: RR interval Partial Correlation (partial-r): 0.1096 [-0.0276, 0.2426] sex, age, birth date, deprivation index, 16 PCs
PPM010142 PSS008470|
Greater Middle Eastern Ancestry|
26 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: RR interval Partial Correlation (partial-r): -0.3743 [-0.9096, 0.628] sex, age, birth date, deprivation index, 16 PCs
PPM010143 PSS008250|
South Asian Ancestry|
166 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: RR interval Partial Correlation (partial-r): 0.0596 [-0.1039, 0.2199] sex, age, birth date, deprivation index, 16 PCs
PPM010144 PSS008028|
East Asian Ancestry|
73 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: RR interval Partial Correlation (partial-r): 0.1051 [-0.1701, 0.365] sex, age, birth date, deprivation index, 16 PCs
PPM010146 PSS008918|
African Ancestry|
61 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: RR interval Partial Correlation (partial-r): 0.0322 [-0.2782, 0.3365] sex, age, birth date, deprivation index, 16 PCs
PPM010145 PSS007814|
African Ancestry|
49 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: RR interval Partial Correlation (partial-r): -0.1946 [-0.5237, 0.1851] sex, age, birth date, deprivation index, 16 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007814 49 individuals African American or Afro-Caribbean Carribean UKB
PSS009142 193 individuals European Poland (NE Europe) UKB
PSS008470 26 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS009368 1,042 individuals European UK (+ Ireland) UKB
PSS008696 226 individuals European Italy (South Europe) UKB
PSS008250 166 individuals South Asian India (South Asia) UKB
PSS008918 61 individuals African unspecified Nigeria (West Africa) UKB
PSS008028 73 individuals East Asian China (East Asia) UKB