Polygenic Score (PGS) ID: PGS001908

Predicted Trait
Reported Trait Red blood cell (erythrocyte) distribution width
Mapped Trait(s) red blood cell distribution width (EFO_0005192)
Additional Trait Information biological measures
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-PLR_erythrocyte_width
Development Method
Name Penalized regression (bigstatsr)
Parameters HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 32,431
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
391,124 individuals European UK (+ Ireland) UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM010147 PSS009400|
European Ancestry|
19,392 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Red blood cell (erythrocyte) distribution width Partial Correlation (partial-r): 0.3342 [0.3217, 0.3467] sex, age, birth date, deprivation index, 16 PCs
PPM010148 PSS009174|
European Ancestry|
3,996 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Red blood cell (erythrocyte) distribution width Partial Correlation (partial-r): 0.3297 [0.3017, 0.3571] sex, age, birth date, deprivation index, 16 PCs
PPM010149 PSS008728|
European Ancestry|
6,422 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Red blood cell (erythrocyte) distribution width Partial Correlation (partial-r): 0.2987 [0.2762, 0.3208] sex, age, birth date, deprivation index, 16 PCs
PPM010150 PSS008502|
Greater Middle Eastern Ancestry|
1,144 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Red blood cell (erythrocyte) distribution width Partial Correlation (partial-r): 0.2615 [0.2062, 0.3152] sex, age, birth date, deprivation index, 16 PCs
PPM010151 PSS008280|
South Asian Ancestry|
6,035 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Red blood cell (erythrocyte) distribution width Partial Correlation (partial-r): 0.2435 [0.2196, 0.2671] sex, age, birth date, deprivation index, 16 PCs
PPM010152 PSS008057|
East Asian Ancestry|
1,757 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Red blood cell (erythrocyte) distribution width Partial Correlation (partial-r): 0.2371 [0.1922, 0.281] sex, age, birth date, deprivation index, 16 PCs
PPM010154 PSS008948|
African Ancestry|
3,680 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Red blood cell (erythrocyte) distribution width Partial Correlation (partial-r): 0.1241 [0.092, 0.1558] sex, age, birth date, deprivation index, 16 PCs
PPM010153 PSS007844|
African Ancestry|
2,328 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Red blood cell (erythrocyte) distribution width Partial Correlation (partial-r): 0.1157 [0.0753, 0.1558] sex, age, birth date, deprivation index, 16 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007844 2,328 individuals African American or Afro-Caribbean Carribean UKB
PSS008948 3,680 individuals African unspecified Nigeria (West Africa) UKB
PSS009174 3,996 individuals European Poland (NE Europe) UKB
PSS008502 1,144 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS008280 6,035 individuals South Asian India (South Asia) UKB
PSS009400 19,392 individuals European UK (+ Ireland) UKB
PSS008728 6,422 individuals European Italy (South Europe) UKB
PSS008057 1,757 individuals East Asian China (East Asia) UKB