Polygenic Score (PGS) ID: PGS001910

Predicted Trait
Reported Trait Ever taken cannabis
Mapped Trait(s) Cannabis use (EFO_0007585)
Additional Trait Information lifestyle and environment
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-PLR_ever_cannabis
Development Method
Name Penalized regression (bigstatsr)
Parameters HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 9,341
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
391,124 individuals European UK (+ Ireland) UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM010163 PSS009402|
European Ancestry|
5,865 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ever taken cannabis Partial Correlation (partial-r): 0.071 [0.0455, 0.0965] sex, age, birth date, deprivation index, 16 PCs
PPM010164 PSS009176|
European Ancestry|
1,104 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ever taken cannabis Partial Correlation (partial-r): 0.0914 [0.0321, 0.1502] sex, age, birth date, deprivation index, 16 PCs
PPM010165 PSS008730|
European Ancestry|
2,006 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ever taken cannabis Partial Correlation (partial-r): 0.0329 [-0.0111, 0.0768] sex, age, birth date, deprivation index, 16 PCs
PPM010166 PSS008504|
Greater Middle Eastern Ancestry|
186 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ever taken cannabis Partial Correlation (partial-r): 0.0068 [-0.1456, 0.159] sex, age, birth date, deprivation index, 16 PCs
PPM010167 PSS008282|
South Asian Ancestry|
784 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ever taken cannabis Partial Correlation (partial-r): -0.0078 [-0.0787, 0.0631] sex, age, birth date, deprivation index, 16 PCs
PPM010169 PSS007846|
African Ancestry|
333 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ever taken cannabis Partial Correlation (partial-r): 0.0465 [-0.0647, 0.1565] sex, age, birth date, deprivation index, 16 PCs
PPM010170 PSS008950|
African Ancestry|
482 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ever taken cannabis Partial Correlation (partial-r): -0.0235 [-0.1145, 0.0679] sex, age, birth date, deprivation index, 16 PCs
PPM010168 PSS008059|
East Asian Ancestry|
405 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ever taken cannabis Partial Correlation (partial-r): -0.0454 [-0.1447, 0.0548] sex, age, birth date, deprivation index, 16 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007846 333 individuals African American or Afro-Caribbean Carribean UKB
PSS008059 405 individuals East Asian China (East Asia) UKB
PSS008950 482 individuals African unspecified Nigeria (West Africa) UKB
PSS008504 186 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS009176 1,104 individuals European Poland (NE Europe) UKB
PSS008730 2,006 individuals European Italy (South Europe) UKB
PSS008282 784 individuals South Asian India (South Asia) UKB
PSS009402 5,865 individuals European UK (+ Ireland) UKB