Polygenic Score (PGS) ID: PGS001918

Predicted Trait
Reported Trait Forced expiratory volume in 1-second (FEV1), Best measure
Mapped Trait(s) forced expiratory volume (EFO_0004314)
Additional Trait Information physical measures
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-PLR_FEV1
Development Method
Name Penalized regression (bigstatsr)
Parameters HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 79,136
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 75%
Greater Middle Eastern: 25%
4 Sample Sets

Development Samples

Score Development/Training
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
391,124 individuals European UK (+ Ireland) UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM010228 PSS009143|
European Ancestry|
2,907 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Forced expiratory volume in 1-second (FEV1), Best measure Partial Correlation (partial-r): 0.2917 [0.2579, 0.3247] sex, age, birth date, deprivation index, 16 PCs
PPM010229 PSS008697|
European Ancestry|
4,520 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Forced expiratory volume in 1-second (FEV1), Best measure Partial Correlation (partial-r): 0.2873 [0.2603, 0.3139] sex, age, birth date, deprivation index, 16 PCs
PPM010230 PSS008471|
Greater Middle Eastern Ancestry|
163 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Forced expiratory volume in 1-second (FEV1), Best measure Partial Correlation (partial-r): 0.3457 [0.1925, 0.4825] sex, age, birth date, deprivation index, 16 PCs
PPM010227 PSS009369|
European Ancestry|
15,118 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Forced expiratory volume in 1-second (FEV1), Best measure Partial Correlation (partial-r): 0.3319 [0.3176, 0.346] sex, age, birth date, deprivation index, 16 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009369 15,118 individuals European UK (+ Ireland) UKB
PSS008471 163 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS009143 2,907 individuals European Poland (NE Europe) UKB
PSS008697 4,520 individuals European Italy (South Europe) UKB