Polygenic Score (PGS) ID: PGS001946

Predicted Trait
Reported Trait C-reactive protein
Mapped Trait(s) C-reactive protein measurement (EFO_0004458)
Additional Trait Information biological measures
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-PLR_log_CRP
Development Method
Name Penalized regression (bigstatsr)
Parameters HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 71,444
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
391,124 individuals European UK (+ Ireland) UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM010443 PSS009430|
European Ancestry|
18,962 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: C-reactive protein Partial Correlation (partial-r): 0.3858 [0.3736, 0.3978] sex, age, birth date, deprivation index, 16 PCs
PPM010444 PSS009204|
European Ancestry|
3,944 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: C-reactive protein Partial Correlation (partial-r): 0.3769 [0.3497, 0.4034] sex, age, birth date, deprivation index, 16 PCs
PPM010445 PSS008758|
European Ancestry|
6,308 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: C-reactive protein Partial Correlation (partial-r): 0.3495 [0.3276, 0.371] sex, age, birth date, deprivation index, 16 PCs
PPM010446 PSS008532|
Greater Middle Eastern Ancestry|
1,124 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: C-reactive protein Partial Correlation (partial-r): 0.3484 [0.2954, 0.3991] sex, age, birth date, deprivation index, 16 PCs
PPM010447 PSS008310|
South Asian Ancestry|
5,978 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: C-reactive protein Partial Correlation (partial-r): 0.3629 [0.3406, 0.3847] sex, age, birth date, deprivation index, 16 PCs
PPM010448 PSS008087|
East Asian Ancestry|
1,710 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: C-reactive protein Partial Correlation (partial-r): 0.3027 [0.2588, 0.3454] sex, age, birth date, deprivation index, 16 PCs
PPM010449 PSS007874|
African Ancestry|
2,339 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: C-reactive protein Partial Correlation (partial-r): 0.215 [0.1758, 0.2534] sex, age, birth date, deprivation index, 16 PCs
PPM010450 PSS008978|
African Ancestry|
3,653 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: C-reactive protein Partial Correlation (partial-r): 0.1982 [0.1667, 0.2292] sex, age, birth date, deprivation index, 16 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008978 3,653 individuals African unspecified Nigeria (West Africa) UKB
PSS009204 3,944 individuals European Poland (NE Europe) UKB
PSS008532 1,124 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS009430 18,962 individuals European UK (+ Ireland) UKB
PSS008758 6,308 individuals European Italy (South Europe) UKB
PSS008310 5,978 individuals South Asian India (South Asia) UKB
PSS008087 1,710 individuals East Asian China (East Asia) UKB
PSS007874 2,339 individuals African American or Afro-Caribbean Carribean UKB