Polygenic Score (PGS) ID: PGS001977

Predicted Trait
Reported Trait Sex hormone binding globulin (SHBG)
Mapped Trait(s) sex hormone-binding globulin measurement (EFO_0004696)
Additional Trait Information biological measures
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-PLR_log_SHBG
Development Method
Name Penalized regression (bigstatsr)
Parameters HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 51,427
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 44.4%
African: 22.2%
East Asian: 11.1%
Greater Middle Eastern: 11.1%
South Asian: 11.1%
9 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM010692 PSS009210|
European Ancestry|
3,563 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sex hormone binding globulin (SHBG) — — Partial Correlation (partial-r): 0.3909 [0.3627, 0.4185] sex, age, birth date, deprivation index, 16 PCs —
PPM010693 PSS008764|
European Ancestry|
5,738 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sex hormone binding globulin (SHBG) — — Partial Correlation (partial-r): 0.4056 [0.3837, 0.427] sex, age, birth date, deprivation index, 16 PCs —
PPM010694 PSS008538|
Greater Middle Eastern Ancestry|
1,025 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sex hormone binding globulin (SHBG) — — Partial Correlation (partial-r): 0.3846 [0.3307, 0.4361] sex, age, birth date, deprivation index, 16 PCs —
PPM010695 PSS008316|
South Asian Ancestry|
5,437 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sex hormone binding globulin (SHBG) — — Partial Correlation (partial-r): 0.3532 [0.3297, 0.3763] sex, age, birth date, deprivation index, 16 PCs —
PPM010696 PSS008093|
East Asian Ancestry|
1,548 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sex hormone binding globulin (SHBG) — — Partial Correlation (partial-r): 0.3607 [0.3163, 0.4035] sex, age, birth date, deprivation index, 16 PCs —
PPM010697 PSS007880|
African Ancestry|
2,140 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sex hormone binding globulin (SHBG) — — Partial Correlation (partial-r): 0.2192 [0.1783, 0.2594] sex, age, birth date, deprivation index, 16 PCs —
PPM010698 PSS008984|
African Ancestry|
3,374 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sex hormone binding globulin (SHBG) — — Partial Correlation (partial-r): 0.1912 [0.1584, 0.2236] sex, age, birth date, deprivation index, 16 PCs —
PPM010691 PSS009436|
European Ancestry|
17,266 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sex hormone binding globulin (SHBG) — — Partial Correlation (partial-r): 0.4274 [0.4152, 0.4396] sex, age, birth date, deprivation index, 16 PCs —
PPM038763 PSS013916|
European Ancestry|
425,240 individuals
 PGP000865 |
Bhatt IS et al. J Assoc Res Otolaryngol (2024)
|Ext.		 Reported Trait: Age-related hearing difficulty β: -0.01802 — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009436 — — 17,266 individuals — European UK (+ Ireland) UKB —
PSS007880 — — 2,140 individuals — African American or Afro-Caribbean Carribean UKB —
PSS008984 — — 3,374 individuals — African unspecified Nigeria (West Africa) UKB —
PSS008538 — — 1,025 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009210 — — 3,563 individuals — European Poland (NE Europe) UKB —
PSS008764 — — 5,738 individuals — European Italy (South Europe) UKB —
PSS008093 — — 1,548 individuals — East Asian China (East Asia) UKB —
PSS013916 — —
[
  • 111,243 cases
  • , 313,997 controls
]
,
46.21 % Male samples
 — European
(British, Irish)		 — UKB —
PSS008316 — — 5,437 individuals — South Asian India (South Asia) UKB —