Polygenic Score (PGS) ID: PGS001979

Predicted Trait
Reported Trait Triglycerides
Mapped Trait(s) triglyceride measurement (EFO_0004530)
Additional Trait Information biological measures
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-PLR_log_triglycerides
Development Method
Name Penalized regression (bigstatsr)
Parameters HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 71,203
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
391,124 individuals European UK (+ Ireland) UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM010707 PSS009467|
European Ancestry|
18,986 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Triglycerides Partial Correlation (partial-r): 0.3705 [0.3582, 0.3827] sex, age, birth date, deprivation index, 16 PCs
PPM010708 PSS009241|
European Ancestry|
3,948 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Triglycerides Partial Correlation (partial-r): 0.3597 [0.3322, 0.3867] sex, age, birth date, deprivation index, 16 PCs
PPM010709 PSS008795|
European Ancestry|
6,319 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Triglycerides Partial Correlation (partial-r): 0.3539 [0.3321, 0.3753] sex, age, birth date, deprivation index, 16 PCs
PPM010710 PSS008569|
Greater Middle Eastern Ancestry|
1,122 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Triglycerides Partial Correlation (partial-r): 0.3051 [0.2505, 0.3577] sex, age, birth date, deprivation index, 16 PCs
PPM010711 PSS008347|
South Asian Ancestry|
5,996 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Triglycerides Partial Correlation (partial-r): 0.3582 [0.3359, 0.3801] sex, age, birth date, deprivation index, 16 PCs
PPM010712 PSS008124|
East Asian Ancestry|
1,716 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Triglycerides Partial Correlation (partial-r): 0.2738 [0.2292, 0.3173] sex, age, birth date, deprivation index, 16 PCs
PPM010713 PSS007911|
African Ancestry|
2,345 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Triglycerides Partial Correlation (partial-r): 0.1921 [0.1526, 0.2309] sex, age, birth date, deprivation index, 16 PCs
PPM010714 PSS009015|
African Ancestry|
3,653 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Triglycerides Partial Correlation (partial-r): 0.1492 [0.1172, 0.1808] sex, age, birth date, deprivation index, 16 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007911 2,345 individuals African American or Afro-Caribbean Carribean UKB
PSS009015 3,653 individuals African unspecified Nigeria (West Africa) UKB
PSS008569 1,122 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS009241 3,948 individuals European Poland (NE Europe) UKB
PSS008795 6,319 individuals European Italy (South Europe) UKB
PSS008124 1,716 individuals East Asian China (East Asia) UKB
PSS008347 5,996 individuals South Asian India (South Asia) UKB
PSS009467 18,986 individuals European UK (+ Ireland) UKB