Polygenic Score (PGS) ID: PGS001981

Predicted Trait
Reported Trait Ventricular rate
Mapped Trait(s) ventricular rate measurement (EFO_0007928)
Additional Trait Information physical measures
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-PLR_log_ventricular_rate
Development Method
Name Penalized regression (bigstatsr)
Parameters HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 6,324
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
391,124 individuals European UK (+ Ireland) UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM010723 PSS009469|
European Ancestry|
1,711 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ventricular rate Partial Correlation (partial-r): 0.1331 [0.086, 0.1796] sex, age, birth date, deprivation index, 16 PCs
PPM010724 PSS009243|
European Ancestry|
329 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ventricular rate Partial Correlation (partial-r): 0.0953 [-0.0164, 0.2047] sex, age, birth date, deprivation index, 16 PCs
PPM010726 PSS008571|
Greater Middle Eastern Ancestry|
50 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ventricular rate Partial Correlation (partial-r): -0.2266 [-0.5425, 0.1456] sex, age, birth date, deprivation index, 16 PCs
PPM010727 PSS008349|
South Asian Ancestry|
307 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ventricular rate Partial Correlation (partial-r): 0.025 [-0.0911, 0.1404] sex, age, birth date, deprivation index, 16 PCs
PPM010728 PSS008126|
East Asian Ancestry|
137 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ventricular rate Partial Correlation (partial-r): -0.0998 [-0.2763, 0.0832] sex, age, birth date, deprivation index, 16 PCs
PPM010729 PSS007913|
African Ancestry|
78 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ventricular rate Partial Correlation (partial-r): 0.0409 [-0.2198, 0.296] sex, age, birth date, deprivation index, 16 PCs
PPM010730 PSS009017|
African Ancestry|
140 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ventricular rate Partial Correlation (partial-r): -0.1197 [-0.2927, 0.0608] sex, age, birth date, deprivation index, 16 PCs
PPM010725 PSS008797|
European Ancestry|
490 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ventricular rate Partial Correlation (partial-r): 0.1205 [0.0304, 0.2087] sex, age, birth date, deprivation index, 16 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008349 307 individuals South Asian India (South Asia) UKB
PSS007913 78 individuals African American or Afro-Caribbean Carribean UKB
PSS008797 490 individuals European Italy (South Europe) UKB
PSS009017 140 individuals African unspecified Nigeria (West Africa) UKB
PSS009243 329 individuals European Poland (NE Europe) UKB
PSS008571 50 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS009469 1,711 individuals European UK (+ Ireland) UKB
PSS008126 137 individuals East Asian China (East Asia) UKB