Polygenic Score (PGS) ID: PGS001989

Predicted Trait
Reported Trait Mean corpuscular haemoglobin
Mapped Trait(s) mean corpuscular hemoglobin (EFO_0004527)
Additional Trait Information biological measures
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-PLR_MCH
Development Method
Name Penalized regression (bigstatsr)
Parameters HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 44,174
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
391,124 individuals European UK (+ Ireland) UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM010787 PSS009377|
European Ancestry|
19,421 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Mean corpuscular haemoglobin Partial Correlation (partial-r): 0.4309 [0.4194, 0.4423] sex, age, birth date, deprivation index, 16 PCs
PPM010788 PSS009151|
European Ancestry|
4,000 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Mean corpuscular haemoglobin Partial Correlation (partial-r): 0.384 [0.3572, 0.4102] sex, age, birth date, deprivation index, 16 PCs
PPM010789 PSS008705|
European Ancestry|
6,435 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Mean corpuscular haemoglobin Partial Correlation (partial-r): 0.317 [0.2948, 0.3388] sex, age, birth date, deprivation index, 16 PCs
PPM010790 PSS008479|
Greater Middle Eastern Ancestry|
1,153 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Mean corpuscular haemoglobin Partial Correlation (partial-r): 0.2578 [0.2026, 0.3114] sex, age, birth date, deprivation index, 16 PCs
PPM010791 PSS008257|
South Asian Ancestry|
6,078 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Mean corpuscular haemoglobin Partial Correlation (partial-r): 0.2698 [0.2462, 0.2929] sex, age, birth date, deprivation index, 16 PCs
PPM010792 PSS008035|
East Asian Ancestry|
1,762 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Mean corpuscular haemoglobin Partial Correlation (partial-r): 0.2299 [0.1849, 0.2739] sex, age, birth date, deprivation index, 16 PCs
PPM010793 PSS007821|
African Ancestry|
2,343 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Mean corpuscular haemoglobin Partial Correlation (partial-r): 0.1586 [0.1187, 0.198] sex, age, birth date, deprivation index, 16 PCs
PPM010794 PSS008925|
African Ancestry|
3,711 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Mean corpuscular haemoglobin Partial Correlation (partial-r): 0.1189 [0.087, 0.1506] sex, age, birth date, deprivation index, 16 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009151 4,000 individuals European Poland (NE Europe) UKB
PSS007821 2,343 individuals African American or Afro-Caribbean Carribean UKB
PSS008257 6,078 individuals South Asian India (South Asia) UKB
PSS009377 19,421 individuals European UK (+ Ireland) UKB
PSS008925 3,711 individuals African unspecified Nigeria (West Africa) UKB
PSS008479 1,153 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS008705 6,435 individuals European Italy (South Europe) UKB
PSS008035 1,762 individuals East Asian China (East Asia) UKB