Polygenic Score (PGS) ID: PGS002005

Predicted Trait
Reported Trait Sitting height
Mapped Trait(s) sitting height measurement (EFO_0011011)
Additional Trait Information physical measures
Released in PGS Catalog: Jan. 10, 2022
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name portability-PLR_sitting_height
Development Method
Name Penalized regression (bigstatsr)
Parameters HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 118,423
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
391,124 individuals European UK (+ Ireland) UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM010919 PSS008146|
East Asian Ancestry|
1,800 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sitting height Partial Correlation (partial-r): 0.3397 [0.298, 0.3802] sex, age, birth date, deprivation index, 16 PCs
PPM010914 PSS009490|
European Ancestry|
19,908 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sitting height Partial Correlation (partial-r): 0.5055 [0.4951, 0.5158] sex, age, birth date, deprivation index, 16 PCs
PPM010915 PSS009264|
European Ancestry|
4,122 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sitting height Partial Correlation (partial-r): 0.487 [0.4633, 0.51] sex, age, birth date, deprivation index, 16 PCs
PPM010916 PSS008818|
European Ancestry|
6,623 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sitting height Partial Correlation (partial-r): 0.4655 [0.4464, 0.4842] sex, age, birth date, deprivation index, 16 PCs
PPM010917 PSS008592|
Greater Middle Eastern Ancestry|
1,175 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sitting height Partial Correlation (partial-r): 0.4025 [0.353, 0.4497] sex, age, birth date, deprivation index, 16 PCs
PPM010918 PSS008370|
South Asian Ancestry|
6,123 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sitting height Partial Correlation (partial-r): 0.3897 [0.3682, 0.4108] sex, age, birth date, deprivation index, 16 PCs
PPM010920 PSS007934|
African Ancestry|
2,443 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sitting height Partial Correlation (partial-r): 0.24 [0.2021, 0.2772] sex, age, birth date, deprivation index, 16 PCs
PPM010921 PSS009038|
African Ancestry|
3,857 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sitting height Partial Correlation (partial-r): 0.2113 [0.1808, 0.2413] sex, age, birth date, deprivation index, 16 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009038 3,857 individuals African unspecified Nigeria (West Africa) UKB
PSS008592 1,175 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS009264 4,122 individuals European Poland (NE Europe) UKB
PSS009490 19,908 individuals European UK (+ Ireland) UKB
PSS008818 6,623 individuals European Italy (South Europe) UKB
PSS008146 1,800 individuals East Asian China (East Asia) UKB
PSS008370 6,123 individuals South Asian India (South Asia) UKB
PSS007934 2,443 individuals African American or Afro-Caribbean Carribean UKB