Polygenic Score (PGS) ID: PGS002052

Predicted Trait
Reported Trait Occlusion and stenosis of precerebral arteries
Mapped Trait(s) occlusion precerebral artery (EFO_0009677)
Additional Trait Information circulatory system
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-ldpred2_433.1
Development Method
Name LDpred2 (bigsnpr)
Parameters LDpred2-auto using HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 490,459
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM011278 PSS009316|
European Ancestry|
19,445 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Occlusion and stenosis of precerebral arteries — — Partial Correlation (partial-r): 0.0199 [0.0058, 0.034] sex, age, birth date, deprivation index, 16 PCs —
PPM011279 PSS009090|
European Ancestry|
4,046 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Occlusion and stenosis of precerebral arteries — — Partial Correlation (partial-r): 0.0001 [-0.0308, 0.031] sex, age, birth date, deprivation index, 16 PCs —
PPM011280 PSS008644|
European Ancestry|
6,521 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Occlusion and stenosis of precerebral arteries — — Partial Correlation (partial-r): 0.0191 [-0.0052, 0.0434] sex, age, birth date, deprivation index, 16 PCs —
PPM011282 PSS008198|
South Asian Ancestry|
6,173 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Occlusion and stenosis of precerebral arteries — — Partial Correlation (partial-r): 0.0003 [-0.0247, 0.0253] sex, age, birth date, deprivation index, 16 PCs —
PPM011283 PSS007980|
East Asian Ancestry|
1,789 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Occlusion and stenosis of precerebral arteries — — Partial Correlation (partial-r): -0.0132 [-0.0598, 0.0334] sex, age, birth date, deprivation index, 16 PCs —
PPM011284 PSS007763|
African Ancestry|
2,407 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Occlusion and stenosis of precerebral arteries — — Partial Correlation (partial-r): 0.0003 [-0.0398, 0.0404] sex, age, birth date, deprivation index, 16 PCs —
PPM011285 PSS008867|
African Ancestry|
3,806 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Occlusion and stenosis of precerebral arteries — — Partial Correlation (partial-r): 0.0054 [-0.0265, 0.0372] sex, age, birth date, deprivation index, 16 PCs —
PPM011281 PSS008418|
Greater Middle Eastern Ancestry|
1,183 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Occlusion and stenosis of precerebral arteries — — Partial Correlation (partial-r): -0.0093 [-0.0667, 0.0482] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009316 — — 19,445 individuals — European UK (+ Ireland) UKB —
PSS008644 — — 6,521 individuals — European Italy (South Europe) UKB —
PSS008198 — — 6,173 individuals — South Asian India (South Asia) UKB —
PSS007980 — — 1,789 individuals — East Asian China (East Asia) UKB —
PSS008418 — — 1,183 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS007763 — — 2,407 individuals — African American or Afro-Caribbean Carribean UKB —
PSS009090 — — 4,046 individuals — European Poland (NE Europe) UKB —
PSS008867 — — 3,806 individuals — African unspecified Nigeria (West Africa) UKB —