Polygenic Score (PGS) ID: PGS002054

Predicted Trait
Reported Trait Abdominal aortic aneurysm
Mapped Trait(s) Abdominal Aortic Aneurysm (EFO_0004214)
Additional Trait Information circulatory system
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-ldpred2_442.11
Development Method
Name LDpred2 (bigsnpr)
Parameters LDpred2-auto using HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 592,187
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
391,124 individuals European UK (+ Ireland) UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM011294 PSS009317|
European Ancestry|
19,545 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Abdominal aortic aneurysm Partial Correlation (partial-r): 0.0144 sex, age, birth date, deprivation index, 16 PCs
PPM011295 PSS009091|
European Ancestry|
4,042 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Abdominal aortic aneurysm Partial Correlation (partial-r): 0.0382 [0.0073, 0.069] sex, age, birth date, deprivation index, 16 PCs
PPM011296 PSS008645|
European Ancestry|
6,542 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Abdominal aortic aneurysm Partial Correlation (partial-r): 0.0139 [-0.0104, 0.0382] sex, age, birth date, deprivation index, 16 PCs
PPM011297 PSS008419|
Greater Middle Eastern Ancestry|
1,183 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Abdominal aortic aneurysm Partial Correlation (partial-r): 0.0222 [-0.0354, 0.0795] sex, age, birth date, deprivation index, 16 PCs
PPM011298 PSS008199|
South Asian Ancestry|
6,205 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Abdominal aortic aneurysm Partial Correlation (partial-r): 0.0007 [-0.0243, 0.0256] sex, age, birth date, deprivation index, 16 PCs
PPM011299 PSS007981|
East Asian Ancestry|
1,791 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Abdominal aortic aneurysm Partial Correlation (partial-r): 0.025 [-0.0216, 0.0715] sex, age, birth date, deprivation index, 16 PCs
PPM011300 PSS007764|
African Ancestry|
2,435 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Abdominal aortic aneurysm Partial Correlation (partial-r): 0.0069 [-0.033, 0.0468] sex, age, birth date, deprivation index, 16 PCs
PPM011301 PSS008868|
African Ancestry|
3,861 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Abdominal aortic aneurysm Partial Correlation (partial-r): -0.0158 [-0.0474, 0.0158] sex, age, birth date, deprivation index, 16 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008868 3,861 individuals African unspecified Nigeria (West Africa) UKB
PSS009317 19,545 individuals European UK (+ Ireland) UKB
PSS008645 6,542 individuals European Italy (South Europe) UKB
PSS008199 6,205 individuals South Asian India (South Asia) UKB
PSS007981 1,791 individuals East Asian China (East Asia) UKB
PSS007764 2,435 individuals African American or Afro-Caribbean Carribean UKB
PSS009091 4,042 individuals European Poland (NE Europe) UKB
PSS008419 1,183 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB