Polygenic Score (PGS) ID: PGS002105

Predicted Trait
Reported Trait Birth weight
Mapped Trait(s) birth weight (EFO_0004344)
Additional Trait Information physical measures
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-ldpred2_birth_weight
Development Method
Name LDpred2 (bigsnpr)
Parameters LDpred2-auto using HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 827,714
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM011696 PSS009388|
European Ancestry|
11,255 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Birth weight — — Partial Correlation (partial-r): 0.2001 [0.1823, 0.2178] sex, age, birth date, deprivation index, 16 PCs —
PPM011697 PSS009162|
European Ancestry|
2,139 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Birth weight — — Partial Correlation (partial-r): 0.1536 [0.1118, 0.1949] sex, age, birth date, deprivation index, 16 PCs —
PPM011698 PSS008716|
European Ancestry|
3,422 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Birth weight — — Partial Correlation (partial-r): 0.1634 [0.1305, 0.1959] sex, age, birth date, deprivation index, 16 PCs —
PPM011699 PSS008490|
Greater Middle Eastern Ancestry|
303 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Birth weight — — Partial Correlation (partial-r): 0.2068 [0.0924, 0.3158] sex, age, birth date, deprivation index, 16 PCs —
PPM011701 PSS008046|
East Asian Ancestry|
714 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Birth weight — — Partial Correlation (partial-r): 0.197 [0.1244, 0.2675] sex, age, birth date, deprivation index, 16 PCs —
PPM011702 PSS007832|
African Ancestry|
840 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Birth weight — — Partial Correlation (partial-r): 0.0764 [0.008, 0.1441] sex, age, birth date, deprivation index, 16 PCs —
PPM011703 PSS008936|
African Ancestry|
791 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Birth weight — — Partial Correlation (partial-r): 0.1227 [0.0526, 0.1917] sex, age, birth date, deprivation index, 16 PCs —
PPM011700 PSS008268|
South Asian Ancestry|
1,505 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Birth weight — — Partial Correlation (partial-r): 0.113 [0.0625, 0.163] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008936 — — 791 individuals — African unspecified Nigeria (West Africa) UKB —
PSS008490 — — 303 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009162 — — 2,139 individuals — European Poland (NE Europe) UKB —
PSS009388 — — 11,255 individuals — European UK (+ Ireland) UKB —
PSS008716 — — 3,422 individuals — European Italy (South Europe) UKB —
PSS008046 — — 714 individuals — East Asian China (East Asia) UKB —
PSS008268 — — 1,505 individuals — South Asian India (South Asia) UKB —
PSS007832 — — 840 individuals — African American or Afro-Caribbean Carribean UKB —