Polygenic Score (PGS) ID: PGS002118

Predicted Trait
Reported Trait PQ interval
Mapped Trait(s) PR interval (EFO_0004462)
Additional Trait Information physical measures
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-ldpred2_ECG_PQ_interval
Development Method
Name LDpred2 (bigsnpr)
Parameters LDpred2-auto using HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 413,539
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM011801 PSS008692|
European Ancestry|
217 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: PQ interval — — Partial Correlation (partial-r): 0.2529 [0.1173, 0.3793] sex, age, birth date, deprivation index, 16 PCs —
PPM011799 PSS009364|
European Ancestry|
992 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: PQ interval — — Partial Correlation (partial-r): 0.1997 [0.1385, 0.2593] sex, age, birth date, deprivation index, 16 PCs —
PPM011800 PSS009138|
European Ancestry|
181 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: PQ interval — — Partial Correlation (partial-r): 0.2082 [0.0553, 0.3516] sex, age, birth date, deprivation index, 16 PCs —
PPM011802 PSS008466|
Greater Middle Eastern Ancestry|
25 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: PQ interval — — Partial Correlation (partial-r): 0.1708 [-0.8377, 0.9152] sex, age, birth date, deprivation index, 16 PCs —
PPM011803 PSS008246|
South Asian Ancestry|
159 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: PQ interval — — Partial Correlation (partial-r): 0.116 [-0.0515, 0.2771] sex, age, birth date, deprivation index, 16 PCs —
PPM011804 PSS008024|
East Asian Ancestry|
73 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: PQ interval — — Partial Correlation (partial-r): 0.1237 [-0.1517, 0.3812] sex, age, birth date, deprivation index, 16 PCs —
PPM011805 PSS007810|
African Ancestry|
49 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: PQ interval — — Partial Correlation (partial-r): 0.1518 [-0.2274, 0.491] sex, age, birth date, deprivation index, 16 PCs —
PPM011806 PSS008914|
African Ancestry|
61 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: PQ interval — — Partial Correlation (partial-r): 0.1868 [-0.1282, 0.4676] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008466 — — 25 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009138 — — 181 individuals — European Poland (NE Europe) UKB —
PSS008692 — — 217 individuals — European Italy (South Europe) UKB —
PSS009364 — — 992 individuals — European UK (+ Ireland) UKB —
PSS008246 — — 159 individuals — South Asian India (South Asia) UKB —
PSS008914 — — 61 individuals — African unspecified Nigeria (West Africa) UKB —
PSS008024 — — 73 individuals — East Asian China (East Asia) UKB —
PSS007810 — — 49 individuals — African American or Afro-Caribbean Carribean UKB —