Polygenic Score (PGS) ID: PGS002122

Predicted Trait
Reported Trait Red blood cell (erythrocyte) distribution width
Mapped Trait(s) Red cell distribution width (EFO_0009188)
Additional Trait Information biological measures
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-ldpred2_erythrocyte_width
Development Method
Name LDpred2 (bigsnpr)
Parameters LDpred2-auto using HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 543,714
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM011832 PSS009174|
European Ancestry|
3,996 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Red blood cell (erythrocyte) distribution width — — Partial Correlation (partial-r): 0.3227 [0.2946, 0.3503] sex, age, birth date, deprivation index, 16 PCs —
PPM011831 PSS009400|
European Ancestry|
19,392 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Red blood cell (erythrocyte) distribution width — — Partial Correlation (partial-r): 0.3341 [0.3215, 0.3465] sex, age, birth date, deprivation index, 16 PCs —
PPM011833 PSS008728|
European Ancestry|
6,422 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Red blood cell (erythrocyte) distribution width — — Partial Correlation (partial-r): 0.2938 [0.2713, 0.3161] sex, age, birth date, deprivation index, 16 PCs —
PPM011834 PSS008502|
Greater Middle Eastern Ancestry|
1,144 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Red blood cell (erythrocyte) distribution width — — Partial Correlation (partial-r): 0.2528 [0.1972, 0.3067] sex, age, birth date, deprivation index, 16 PCs —
PPM011835 PSS008280|
South Asian Ancestry|
6,035 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Red blood cell (erythrocyte) distribution width — — Partial Correlation (partial-r): 0.2424 [0.2185, 0.266] sex, age, birth date, deprivation index, 16 PCs —
PPM011836 PSS008057|
East Asian Ancestry|
1,757 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Red blood cell (erythrocyte) distribution width — — Partial Correlation (partial-r): 0.2289 [0.1838, 0.273] sex, age, birth date, deprivation index, 16 PCs —
PPM011837 PSS007844|
African Ancestry|
2,328 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Red blood cell (erythrocyte) distribution width — — Partial Correlation (partial-r): 0.0986 [0.058, 0.1388] sex, age, birth date, deprivation index, 16 PCs —
PPM011838 PSS008948|
African Ancestry|
3,680 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Red blood cell (erythrocyte) distribution width — — Partial Correlation (partial-r): 0.1434 [0.1115, 0.175] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007844 — — 2,328 individuals — African American or Afro-Caribbean Carribean UKB —
PSS008948 — — 3,680 individuals — African unspecified Nigeria (West Africa) UKB —
PSS009174 — — 3,996 individuals — European Poland (NE Europe) UKB —
PSS008502 — — 1,144 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS008280 — — 6,035 individuals — South Asian India (South Asia) UKB —
PSS009400 — — 19,392 individuals — European UK (+ Ireland) UKB —
PSS008728 — — 6,422 individuals — European Italy (South Europe) UKB —
PSS008057 — — 1,757 individuals — East Asian China (East Asia) UKB —