Polygenic Score (PGS) ID: PGS002135

Predicted Trait
Reported Trait Fluid intelligence score
Mapped Trait(s) intelligence (EFO_0004337)
Additional Trait Information physical measures
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-ldpred2_fluid_intelligence
Development Method
Name LDpred2 (bigsnpr)
Parameters LDpred2-auto using HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 903,259
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM011938 PSS008954|
African Ancestry|
323 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Fluid intelligence score — — Partial Correlation (partial-r): 0.0494 [-0.0636, 0.1612] sex, age, birth date, deprivation index, 16 PCs —
PPM011931 PSS009406|
European Ancestry|
5,092 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Fluid intelligence score — — Partial Correlation (partial-r): 0.1998 [0.1733, 0.2261] sex, age, birth date, deprivation index, 16 PCs —
PPM011932 PSS009180|
European Ancestry|
984 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Fluid intelligence score — — Partial Correlation (partial-r): 0.1048 [0.0419, 0.1668] sex, age, birth date, deprivation index, 16 PCs —
PPM011933 PSS008734|
European Ancestry|
1,846 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Fluid intelligence score — — Partial Correlation (partial-r): 0.1987 [0.1542, 0.2423] sex, age, birth date, deprivation index, 16 PCs —
PPM011934 PSS008508|
Greater Middle Eastern Ancestry|
158 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Fluid intelligence score — — Partial Correlation (partial-r): 0.0685 [-0.0997, 0.233] sex, age, birth date, deprivation index, 16 PCs —
PPM011935 PSS008286|
South Asian Ancestry|
653 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Fluid intelligence score — — Partial Correlation (partial-r): 0.1703 [0.0936, 0.245] sex, age, birth date, deprivation index, 16 PCs —
PPM011936 PSS008063|
East Asian Ancestry|
345 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Fluid intelligence score — — Partial Correlation (partial-r): 0.1364 [0.0281, 0.2416] sex, age, birth date, deprivation index, 16 PCs —
PPM011937 PSS007850|
African Ancestry|
266 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Fluid intelligence score — — Partial Correlation (partial-r): 0.1361 [0.0112, 0.2568] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008508 — — 158 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS007850 — — 266 individuals — African American or Afro-Caribbean Carribean UKB —
PSS008286 — — 653 individuals — South Asian India (South Asia) UKB —
PSS008734 — — 1,846 individuals — European Italy (South Europe) UKB —
PSS008954 — — 323 individuals — African unspecified Nigeria (West Africa) UKB —
PSS009180 — — 984 individuals — European Poland (NE Europe) UKB —
PSS009406 — — 5,092 individuals — European UK (+ Ireland) UKB —
PSS008063 — — 345 individuals — East Asian China (East Asia) UKB —