Polygenic Score (PGS) ID: PGS002144

Predicted Trait
Reported Trait Trouble falling asleep
Mapped Trait(s) Sleep Disorder (EFO_0008568)
Additional Trait Information symptoms
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-ldpred2_hard_falling_asleep
Development Method
Name LDpred2 (bigsnpr)
Parameters LDpred2-auto using HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 539,784
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM011999 PSS009414|
European Ancestry|
2,491 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Trouble falling asleep — — Partial Correlation (partial-r): 0.0646 [0.0253, 0.1038] sex, age, birth date, deprivation index, 16 PCs —
PPM012000 PSS009188|
European Ancestry|
490 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Trouble falling asleep — — Partial Correlation (partial-r): 0.0519 [-0.0387, 0.1417] sex, age, birth date, deprivation index, 16 PCs —
PPM012001 PSS008742|
European Ancestry|
898 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Trouble falling asleep — — Partial Correlation (partial-r): -0.0252 [-0.0912, 0.041] sex, age, birth date, deprivation index, 16 PCs —
PPM012002 PSS008516|
Greater Middle Eastern Ancestry|
75 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Trouble falling asleep — — Partial Correlation (partial-r): 0.0283 [-0.2388, 0.2914] sex, age, birth date, deprivation index, 16 PCs —
PPM012003 PSS008294|
South Asian Ancestry|
311 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Trouble falling asleep — — Partial Correlation (partial-r): 0.062 [-0.0534, 0.1757] sex, age, birth date, deprivation index, 16 PCs —
PPM012004 PSS008071|
East Asian Ancestry|
147 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Trouble falling asleep — — Partial Correlation (partial-r): 0.0992 [-0.0763, 0.2688] sex, age, birth date, deprivation index, 16 PCs —
PPM012005 PSS007858|
African Ancestry|
149 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Trouble falling asleep — — Partial Correlation (partial-r): -0.0892 [-0.258, 0.085] sex, age, birth date, deprivation index, 16 PCs —
PPM012006 PSS008962|
African Ancestry|
151 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Trouble falling asleep — — Partial Correlation (partial-r): -0.0423 [-0.2123, 0.1301] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009188 — — 490 individuals — European Poland (NE Europe) UKB —
PSS008516 — — 75 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009414 — — 2,491 individuals — European UK (+ Ireland) UKB —
PSS008742 — — 898 individuals — European Italy (South Europe) UKB —
PSS008294 — — 311 individuals — South Asian India (South Asia) UKB —
PSS008071 — — 147 individuals — East Asian China (East Asia) UKB —
PSS007858 — — 149 individuals — African American or Afro-Caribbean Carribean UKB —
PSS008962 — — 151 individuals — African unspecified Nigeria (West Africa) UKB —