Polygenic Score (PGS) ID: PGS002151

Predicted Trait
Reported Trait Handedness (chirality/laterality)
Mapped Trait(s) handedness (EFO_0009902)
Additional Trait Information physical measures
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-ldpred2_left_handed
Development Method
Name LDpred2 (bigsnpr)
Parameters LDpred2-auto using HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 734,236
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012055 PSS009420|
European Ancestry|
19,662 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Handedness (chirality/laterality) — — Partial Correlation (partial-r): 0.0253 [0.0113, 0.0392] sex, age, birth date, deprivation index, 16 PCs —
PPM012056 PSS009194|
European Ancestry|
4,015 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Handedness (chirality/laterality) — — Partial Correlation (partial-r): -0.0105 [-0.0415, 0.0205] sex, age, birth date, deprivation index, 16 PCs —
PPM012057 PSS008748|
European Ancestry|
6,485 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Handedness (chirality/laterality) — — Partial Correlation (partial-r): 0.0171 [-0.0072, 0.0415] sex, age, birth date, deprivation index, 16 PCs —
PPM012058 PSS008522|
Greater Middle Eastern Ancestry|
1,137 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Handedness (chirality/laterality) — — Partial Correlation (partial-r): 0.0424 [-0.0163, 0.1008] sex, age, birth date, deprivation index, 16 PCs —
PPM012059 PSS008300|
South Asian Ancestry|
6,079 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Handedness (chirality/laterality) — — Partial Correlation (partial-r): 0.0255 sex, age, birth date, deprivation index, 16 PCs —
PPM012060 PSS008077|
East Asian Ancestry|
1,737 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Handedness (chirality/laterality) — — Partial Correlation (partial-r): 0.033 [-0.0143, 0.0802] sex, age, birth date, deprivation index, 16 PCs —
PPM012061 PSS007864|
African Ancestry|
2,424 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Handedness (chirality/laterality) — — Partial Correlation (partial-r): 0.0368 [-0.0031, 0.0767] sex, age, birth date, deprivation index, 16 PCs —
PPM012062 PSS008968|
African Ancestry|
3,788 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Handedness (chirality/laterality) — — Partial Correlation (partial-r): 0.0029 [-0.029, 0.0349] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008968 — — 3,788 individuals — African unspecified Nigeria (West Africa) UKB —
PSS008522 — — 1,137 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009194 — — 4,015 individuals — European Poland (NE Europe) UKB —
PSS009420 — — 19,662 individuals — European UK (+ Ireland) UKB —
PSS008748 — — 6,485 individuals — European Italy (South Europe) UKB —
PSS008300 — — 6,079 individuals — South Asian India (South Asia) UKB —
PSS008077 — — 1,737 individuals — East Asian China (East Asia) UKB —
PSS007864 — — 2,424 individuals — African American or Afro-Caribbean Carribean UKB —