Polygenic Score (PGS) ID: PGS002167

Predicted Trait
Reported Trait Eosinophil percentage
Mapped Trait(s) eosinophil percentage of leukocytes (EFO_0007991)
Additional Trait Information biological measures
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-ldpred2_log_eosinophil_perc
Development Method
Name LDpred2 (bigsnpr)
Parameters LDpred2-auto using HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 593,459
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012184 PSS009216|
European Ancestry|
2,282 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Eosinophil percentage — — Partial Correlation (partial-r): 0.2199 [0.1803, 0.2587] sex, age, birth date, deprivation index, 16 PCs —
PPM012185 PSS008770|
European Ancestry|
3,365 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Eosinophil percentage — — Partial Correlation (partial-r): 0.1751 [0.142, 0.2077] sex, age, birth date, deprivation index, 16 PCs —
PPM012186 PSS008544|
Greater Middle Eastern Ancestry|
676 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Eosinophil percentage — — Partial Correlation (partial-r): 0.18 [0.1049, 0.253] sex, age, birth date, deprivation index, 16 PCs —
PPM012187 PSS008322|
South Asian Ancestry|
4,224 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Eosinophil percentage — — Partial Correlation (partial-r): 0.1683 [0.1388, 0.1976] sex, age, birth date, deprivation index, 16 PCs —
PPM012188 PSS008099|
East Asian Ancestry|
983 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Eosinophil percentage — — Partial Correlation (partial-r): 0.1159 [0.0531, 0.1778] sex, age, birth date, deprivation index, 16 PCs —
PPM012189 PSS007886|
African Ancestry|
1,291 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Eosinophil percentage — — Partial Correlation (partial-r): 0.0644 [0.0095, 0.119] sex, age, birth date, deprivation index, 16 PCs —
PPM012190 PSS008990|
African Ancestry|
2,100 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Eosinophil percentage — — Partial Correlation (partial-r): 0.091 [0.0482, 0.1335] sex, age, birth date, deprivation index, 16 PCs —
PPM012183 PSS009442|
European Ancestry|
11,529 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Eosinophil percentage — — Partial Correlation (partial-r): 0.2043 [0.1867, 0.2217] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008770 — — 3,365 individuals — European Italy (South Europe) UKB —
PSS007886 — — 1,291 individuals — African American or Afro-Caribbean Carribean UKB —
PSS009442 — — 11,529 individuals — European UK (+ Ireland) UKB —
PSS009216 — — 2,282 individuals — European Poland (NE Europe) UKB —
PSS008990 — — 2,100 individuals — African unspecified Nigeria (West Africa) UKB —
PSS008544 — — 676 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS008322 — — 4,224 individuals — South Asian India (South Asia) UKB —
PSS008099 — — 983 individuals — East Asian China (East Asia) UKB —