Polygenic Score (PGS) ID: PGS002176

Predicted Trait
Reported Trait Hip circumference
Mapped Trait(s) hip circumference (EFO_0005093)
Additional Trait Information physical measures
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-ldpred2_log_hip_circ
Development Method
Name LDpred2 (bigsnpr)
Parameters LDpred2-auto using HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 977,411
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012255 PSS009449|
European Ancestry|
19,965 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hip circumference — — Partial Correlation (partial-r): 0.3358 [0.3234, 0.3481] sex, age, birth date, deprivation index, 16 PCs —
PPM012256 PSS009223|
European Ancestry|
4,125 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hip circumference — — Partial Correlation (partial-r): 0.3499 [0.3228, 0.3765] sex, age, birth date, deprivation index, 16 PCs —
PPM012257 PSS008777|
European Ancestry|
6,637 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hip circumference — — Partial Correlation (partial-r): 0.3202 [0.2984, 0.3417] sex, age, birth date, deprivation index, 16 PCs —
PPM012258 PSS008551|
Greater Middle Eastern Ancestry|
1,181 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hip circumference — — Partial Correlation (partial-r): 0.3271 [0.2747, 0.3775] sex, age, birth date, deprivation index, 16 PCs —
PPM012259 PSS008329|
South Asian Ancestry|
6,267 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hip circumference — — Partial Correlation (partial-r): 0.2877 [0.2648, 0.3103] sex, age, birth date, deprivation index, 16 PCs —
PPM012260 PSS008106|
East Asian Ancestry|
1,802 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hip circumference — — Partial Correlation (partial-r): 0.2616 [0.2178, 0.3043] sex, age, birth date, deprivation index, 16 PCs —
PPM012261 PSS007893|
African Ancestry|
2,456 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hip circumference — — Partial Correlation (partial-r): 0.1822 [0.1435, 0.2203] sex, age, birth date, deprivation index, 16 PCs —
PPM012262 PSS008997|
African Ancestry|
3,867 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hip circumference — — Partial Correlation (partial-r): 0.1523 [0.1212, 0.183] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008997 — — 3,867 individuals — African unspecified Nigeria (West Africa) UKB —
PSS009223 — — 4,125 individuals — European Poland (NE Europe) UKB —
PSS008551 — — 1,181 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS008329 — — 6,267 individuals — South Asian India (South Asia) UKB —
PSS009449 — — 19,965 individuals — European UK (+ Ireland) UKB —
PSS008777 — — 6,637 individuals — European Italy (South Europe) UKB —
PSS008106 — — 1,802 individuals — East Asian China (East Asia) UKB —
PSS007893 — — 2,456 individuals — African American or Afro-Caribbean Carribean UKB —