Polygenic Score (PGS) ID: PGS002204

Predicted Trait
Reported Trait Hair/balding pattern
Mapped Trait(s) balding measurement (EFO_0007825)
Additional Trait Information sex-specific factors
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-ldpred2_M_less_hair
Development Method
Name LDpred2 (bigsnpr)
Parameters LDpred2-auto using HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 593,179
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012479 PSS009379|
European Ancestry|
4,285 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hair/balding pattern — — Partial Correlation (partial-r): 0.4597 [0.4357, 0.483] sex, age, birth date, deprivation index, 16 PCs —
PPM012480 PSS009153|
European Ancestry|
707 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hair/balding pattern — — Partial Correlation (partial-r): 0.3947 [0.3296, 0.4559] sex, age, birth date, deprivation index, 16 PCs —
PPM012481 PSS008707|
European Ancestry|
1,357 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hair/balding pattern — — Partial Correlation (partial-r): 0.4151 [0.3697, 0.4585] sex, age, birth date, deprivation index, 16 PCs —
PPM012483 PSS008259|
South Asian Ancestry|
1,484 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hair/balding pattern — — Partial Correlation (partial-r): 0.3043 [0.257, 0.35] sex, age, birth date, deprivation index, 16 PCs —
PPM012484 PSS008037|
East Asian Ancestry|
261 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hair/balding pattern — — Partial Correlation (partial-r): 0.1848 [0.0601, 0.3039] sex, age, birth date, deprivation index, 16 PCs —
PPM012485 PSS007823|
African Ancestry|
375 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hair/balding pattern — — Partial Correlation (partial-r): 0.2965 [0.1985, 0.3886] sex, age, birth date, deprivation index, 16 PCs —
PPM012486 PSS008927|
African Ancestry|
760 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hair/balding pattern — — Partial Correlation (partial-r): 0.1836 [0.1131, 0.2523] sex, age, birth date, deprivation index, 16 PCs —
PPM012482 PSS008481|
Greater Middle Eastern Ancestry|
297 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hair/balding pattern — — Partial Correlation (partial-r): 0.376 [0.2703, 0.4727] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008037 — — 261 individuals — East Asian China (East Asia) UKB —
PSS009379 — — 4,285 individuals — European UK (+ Ireland) UKB —
PSS007823 — — 375 individuals — African American or Afro-Caribbean Carribean UKB —
PSS008707 — — 1,357 individuals — European Italy (South Europe) UKB —
PSS008927 — — 760 individuals — African unspecified Nigeria (West Africa) UKB —
PSS008481 — — 297 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009153 — — 707 individuals — European Poland (NE Europe) UKB —
PSS008259 — — 1,484 individuals — South Asian India (South Asia) UKB —