Polygenic Score (PGS) ID: PGS002220

Predicted Trait
Reported Trait Hair color (natural, before greying)
Mapped Trait(s) hair colour measurement (EFO_0007822)
Additional Trait Information physical measures
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-ldpred2_red_hair
Development Method
Name LDpred2 (bigsnpr)
Parameters LDpred2-auto using HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 21,400
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 42.9%
African: 28.6%
Greater Middle Eastern: 14.3%
South Asian: 14.3%
7 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012607 PSS009486|
European Ancestry|
19,713 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hair colour (natural, before greying) — — Partial Correlation (partial-r): 0.4428 [0.4315, 0.454] sex, age, birth date, deprivation index, 16 PCs —
PPM012608 PSS009260|
European Ancestry|
4,046 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hair colour (natural, before greying) — — Partial Correlation (partial-r): 0.3315 [0.3037, 0.3587] sex, age, birth date, deprivation index, 16 PCs —
PPM012609 PSS008814|
European Ancestry|
6,570 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hair colour (natural, before greying) — — Partial Correlation (partial-r): 0.3267 [0.3049, 0.3481] sex, age, birth date, deprivation index, 16 PCs —
PPM012610 PSS008588|
Greater Middle Eastern Ancestry|
1,135 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hair colour (natural, before greying) — — Partial Correlation (partial-r): 0.319 [0.2653, 0.3708] sex, age, birth date, deprivation index, 16 PCs —
PPM012611 PSS008366|
South Asian Ancestry|
6,131 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hair colour (natural, before greying) — — Partial Correlation (partial-r): 0.041 [0.016, 0.066] sex, age, birth date, deprivation index, 16 PCs —
PPM012612 PSS007930|
African Ancestry|
2,419 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hair colour (natural, before greying) — — Partial Correlation (partial-r): -0.0113 [-0.0513, 0.0287] sex, age, birth date, deprivation index, 16 PCs —
PPM012613 PSS009034|
African Ancestry|
3,836 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hair colour (natural, before greying) — — Partial Correlation (partial-r): -0.0283 [-0.06, 0.0034] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009034 — — 3,836 individuals — African unspecified Nigeria (West Africa) UKB —
PSS009260 — — 4,046 individuals — European Poland (NE Europe) UKB —
PSS008588 — — 1,135 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS008366 — — 6,131 individuals — South Asian India (South Asia) UKB —
PSS009486 — — 19,713 individuals — European UK (+ Ireland) UKB —
PSS008814 — — 6,570 individuals — European Italy (South Europe) UKB —
PSS007930 — — 2,419 individuals — African American or Afro-Caribbean Carribean UKB —