Polygenic Score (PGS) ID: PGS002251

Predicted Trait
Reported Trait Body mass index (BMI)
Mapped Trait(s) body mass index (EFO_0004340)
Released in PGS Catalog: Jan. 24, 2022
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Score Details

Score Construction
PGS Name PRS97_BMI
Development Method
Name Genome-wide significant variants
Parameters NR
Variants
Original Genome Build NR
Number of Variants 97
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000278
Citation (link to publication) Dashti HS et al. BMC Med (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 99.1%
Hispanic or Latin American: 0.5%
African: 0.4%
238,944 individuals (100%)
PGS Evaluation
European: 50%
Multi-ancestry (including European): 50%
  • European
  • Not Reported
2 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST002783
Europe PMC: 25673413
 236,781 individuals European NR
GWAS Catalog: GCST002783
Europe PMC: 25673413
 887 individuals African American or Afro-Caribbean NR
GWAS Catalog: GCST002783
Europe PMC: 25673413
 1,276 individuals Hispanic or Latin American NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012804 PSS009565|
European Ancestry|
33,511 individuals
 PGP000278 |
Dashti HS et al. BMC Med (2022)
 Reported Trait: Body mass index β: 0.83 [0.76, 0.9] — — age, sex, genotyping array, and 5 PCs of ancestry beta unit kg/m2
PPM022498 PSS011974|
Multi-ancestry (including European)|
6,767 individuals
 PGP000720 |
Masip G et al. Obesity (Silver Spring) (2023)
|Ext.		 Reported Trait: Waist circumference β: 0.05 [0.02, 0.08] — — age, sex, principal components of ancestry, alcohol intake, smoking, education, sleeping time, income, anxiety, physical activity, energy intake, and energy misreporter status —
PPM022499 PSS011974|
Multi-ancestry (including European)|
6,767 individuals
 PGP000720 |
Masip G et al. Obesity (Silver Spring) (2023)
|Ext.		 Reported Trait: BMI β: 0.09 [0.05, 0.12] — — age, sex, principal components of ancestry, alcohol intake, smoking, education, sleeping time, income, anxiety, physical activity, energy intake, and energy misreporter status —
PPM022500 PSS011974|
Multi-ancestry (including European)|
6,767 individuals
 PGP000720 |
Masip G et al. Obesity (Silver Spring) (2023)
|Ext.		 Reported Trait: Body fat percentage β: 0.06 [0.04, 0.09] — — age, sex, principal components of ancestry, alcohol intake, smoking, education, sleeping time, income, anxiety, physical activity, energy intake, and energy misreporter status —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009565 Clinically measured BMI — 33,511 individuals,
46.9 % Male samples
 Mean = 60.2 years
Sd = 16.9 years		 European — MGBB —
PSS011974 — — 6,251 individuals — European — CARTaGENE —
PSS011974 — — 516 individuals — Not reported — CARTaGENE —