Polygenic Score (PGS) ID: PGS002254

Predicted Trait
Reported Trait Physical activity (self-reported)
Mapped Trait(s)
Additional Trait Information UK Biobank Data-Field 884
Released in PGS Catalog: Feb. 16, 2022
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name PRS_reported
Development Method
Name LDpred
Parameters HapMap3 variants, MAF > 5%, excluding MHC region (GRCh37: 6p22.1–21.3)
Variants
Original Genome Build GRCh37
Number of Variants 1,142,416
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000280
Citation (link to publication) Kujala UM et al. Med Sci Sports Exerc (2020)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
321,309 individuals (100%)
PGS Evaluation
European: 100%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
— 321,309 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012823 PSS009569|
European Ancestry|
11,528 individuals
 PGP000280 |
Kujala UM et al. Med Sci Sports Exerc (2020)
 Reported Trait: Daily leisure-time physical activity (MET score) β: 0.1717 (0.0323) — ΔR2 (%): 0.25 age, sex, and four genetic principal components —
PPM012824 PSS009571|
European Ancestry|
4,061 individuals
 PGP000280 |
Kujala UM et al. Med Sci Sports Exerc (2020)
 Reported Trait: Daily leisure-time physical activity (MET score) β: 0.0355 (0.0113) — ΔR2 (%): 0.24 age, sex, and four genetic principal components —
PPM021392 PSS011726|
European Ancestry|
47,148 individuals
 PGP000653 |
Tynkkynen NP et al. Eur J Epidemiol (2023)
|Ext.		 Reported Trait: Self-reported leisure time physical activity β: 0.282 [0.211, 0.354] — R²: 0.014 Age, sex, 10 PCs —
PPM021393 PSS011726|
European Ancestry|
47,148 individuals
 PGP000653 |
Tynkkynen NP et al. Eur J Epidemiol (2023)
|Ext.		 Reported Trait: Waist circumference β: -0.003 [-0.004, -0.002] — R²: 0.137 Age, sex, 10 PCs —
PPM021394 PSS011726|
European Ancestry|
47,148 individuals
 PGP000653 |
Tynkkynen NP et al. Eur J Epidemiol (2023)
|Ext.		 Reported Trait: Body mass index β: -0.002 [-0.004, -0.001] — R²: 0.026 Age, sex, 10 PCs —
PPM021395 PSS011726|
European Ancestry|
47,148 individuals
 PGP000653 |
Tynkkynen NP et al. Eur J Epidemiol (2023)
|Ext.		 Reported Trait: HDL cholesterol β: 0.004 [0.002, 0.006] — R²: 0.134 Age, sex, 10 PCs —
PPM021396 PSS011725|
European Ancestry|
24,960 individuals
 PGP000653 |
Tynkkynen NP et al. Eur J Epidemiol (2023)
|Ext.		 Reported Trait: Stroke HR: 0.94 [0.903, 0.978] — — — —
PPM021397 PSS011725|
European Ancestry|
24,960 individuals
 PGP000653 |
Tynkkynen NP et al. Eur J Epidemiol (2023)
|Ext.		 Reported Trait: Hypertensive diseases HR: 0.97 [0.951, 0.99] — — — —
PPM021398 PSS011725|
European Ancestry|
24,960 individuals
 PGP000653 |
Tynkkynen NP et al. Eur J Epidemiol (2023)
|Ext.		 Reported Trait: Type 2 diabetes HR: 0.935 [0.902, 0.97] — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011726 — — 47,148 individuals,
45.9 % Male samples
 Mean = 52.9 years
Sd = 15.8 years		 European — HUNT —
PSS009569 — — 11,528 individuals,
46.0 % Male samples
 Mean = 44.0 years European
(Finnish)		 — FTC —
PSS011725 — — 24,960 individuals,
46.5 % Male samples
 Mean = 59.1 years
Sd = 14.6 years		 European — HUNT —
PSS009571 — — 4,061 individuals,
48.0 % Male samples
 Mean = 46.0 years European
(Finnish)		 — NFBC —