Polygenic Score (PGS) ID: PGS002255

Predicted Trait
Reported Trait Physical activity (measured)
Mapped Trait(s) physical activity measurement (EFO_0008002)
Released in PGS Catalog: Feb. 16, 2022
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Score Details

Score Construction
PGS Name PRS_measured
Development Method
Name LDpred
Parameters HapMap3 variants, MAF > 5%, excluding MHC region (GRCh37: 6p22.1–21.3)
Variants
Original Genome Build GRCh37
Number of Variants 1,140,182
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000280
Citation (link to publication) Kujala UM et al. Med Sci Sports Exerc (2020)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
91,105 individuals (100%)
PGS Evaluation
European: 100%
3 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST006912
Europe PMC: 30531941
 91,105 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012825 PSS009569|
European Ancestry|
11,528 individuals
 PGP000280 |
Kujala UM et al. Med Sci Sports Exerc (2020)
 Reported Trait: Daily leisure-time physical activity (MET score) β: 0.0908 (0.0321) — ΔR2 (%): 0.07 age, sex, and four genetic principal components —
PPM012826 PSS009571|
European Ancestry|
4,061 individuals
 PGP000280 |
Kujala UM et al. Med Sci Sports Exerc (2020)
 Reported Trait: Daily leisure-time physical activity (MET score) β: 0.0405 (0.0112) — ΔR2 (%): 0.32 age, sex, and four genetic principal components —
PPM012827 PSS009570|
European Ancestry|
765 individuals
 PGP000280 |
Kujala UM et al. Med Sci Sports Exerc (2020)
 Reported Trait: Daily moderate-to-vigorous physical activity β: 2.497 (1.093) — ΔR2 (%): 0.9 age, sex, and four genetic principal components —
PPM012828 PSS009571|
European Ancestry|
4,061 individuals
 PGP000280 |
Kujala UM et al. Med Sci Sports Exerc (2020)
 Reported Trait: Daily moderate-to-vigorous physical activity β: 0.162 (0.0335) — ΔR2 (%): 0.62 age, sex, and four genetic principal components —
PPM012829 PSS009570|
European Ancestry|
765 individuals
 PGP000280 |
Kujala UM et al. Med Sci Sports Exerc (2020)
 Reported Trait: Daily steps β: 369.8 (123.3) — ΔR2 (%): 1.44 age, sex, and four genetic principal components —
PPM012830 PSS009571|
European Ancestry|
4,061 individuals
 PGP000280 |
Kujala UM et al. Med Sci Sports Exerc (2020)
 Reported Trait: Daily steps β: 365.82 (64.04) — ΔR2 (%): 0.96 age, sex, and four genetic principal components —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009569 — — 11,528 individuals,
46.0 % Male samples
 Mean = 44.0 years European
(Finnish)		 — FTC —
PSS009570 — — 765 individuals,
46.0 % Male samples
 Mean = 73.0 years European
(Finnish)		 — NR MOBILETWIN Study
PSS009571 — — 4,061 individuals,
48.0 % Male samples
 Mean = 46.0 years European
(Finnish)		 — NFBC —