Polygenic Score (PGS) ID: PGS002258

Predicted Trait
Reported Trait Diastolic blood pressure
Mapped Trait(s) diastolic blood pressure (EFO_0006336)
Additional Trait Information Score is used in a combined blood pressure score by taking the average between GRS901_SBP and GRS901_DBP
Released in PGS Catalog: Feb. 16, 2022
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PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name GRS901_DBP
Development Method
Name Genome-wide significant variants
Parameters weighted GRSs for all pairwise-independent, LD-filtered (r2 < 0.1) previously reported variants and 535 genome-wide significant SNPs combined
Variants
Original Genome Build GRCh37
Number of Variants 885
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000283
Citation (link to publication) Evangelou E et al. Nat Genet (2018)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
757,601 individuals (100%)
PGS Evaluation
European: 40%
Not Reported: 20%
African: 20%
South Asian: 20%
5 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST006627
Europe PMC: 30224653
 757,601 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012847 PSS009574|
European Ancestry|
14,004 individuals
 PGP000283 |
Evangelou E et al. Nat Genet (2018)
 Reported Trait: Systolic blood pressure β: 2.06 [1.79, 2.32] — — — *Note performance is based on the average between GRS901_SBP and GRS_901_DBP
PPM012848 PSS009574|
European Ancestry|
14,004 individuals
 PGP000283 |
Evangelou E et al. Nat Genet (2018)
 Reported Trait: Diastolic blood pressure β: 1.64 [1.46, 1.81] — — — *Note performance is based on the average between GRS901_SBP and GRS_901_DBP
PPM012849 PSS009574|
European Ancestry|
14,004 individuals
 PGP000283 |
Evangelou E et al. Nat Genet (2018)
 Reported Trait: Pulse pressure β: 0.42 [0.25, 0.58] — — — *Note performance is based on the average between GRS901_SBP and GRS_901_DBP
PPM012850 PSS009574|
European Ancestry|
14,004 individuals
 PGP000283 |
Evangelou E et al. Nat Genet (2018)
 Reported Trait: Hypertension OR: 1.27 [1.23, 1.32] — — — *Note performance is based on the average between GRS901_SBP and GRS_901_DBP
PPM012851 PSS009575|
African Ancestry|
6,970 individuals
 PGP000283 |
Evangelou E et al. Nat Genet (2018)
 Reported Trait: Systolic blood pressure β: 2.38 [1.85, 2.9] — — — *Note performance is based on the average between GRS901_SBP and GRS_901_DBP
PPM012852 PSS009575|
African Ancestry|
6,970 individuals
 PGP000283 |
Evangelou E et al. Nat Genet (2018)
 Reported Trait: Diastolic blood pressure β: 1.39 [1.09, 1.7] — — — *Note performance is based on the average between GRS901_SBP and GRS_901_DBP
PPM012853 PSS009575|
African Ancestry|
6,970 individuals
 PGP000283 |
Evangelou E et al. Nat Genet (2018)
 Reported Trait: Pulse pressure β: 0.99 [0.65, 1.32] — — — *Note performance is based on the average between GRS901_SBP and GRS_901_DBP
PPM012854 PSS009575|
African Ancestry|
6,970 individuals
 PGP000283 |
Evangelou E et al. Nat Genet (2018)
 Reported Trait: Hypertension OR: 1.26 [1.2, 1.33] — — — *Note performance is based on the average between GRS901_SBP and GRS_901_DBP
PPM012855 PSS009576|
South Asian Ancestry|
8,827 individuals
 PGP000283 |
Evangelou E et al. Nat Genet (2018)
 Reported Trait: Systolic blood pressure β: 2.58 [2.13, 3.03] — — — *Note performance is based on the average between GRS901_SBP and GRS_901_DBP
PPM012856 PSS009576|
South Asian Ancestry|
8,827 individuals
 PGP000283 |
Evangelou E et al. Nat Genet (2018)
 Reported Trait: Diastolic blood pressure β: 1.49 [1.25, 1.74] — — — *Note performance is based on the average between GRS901_SBP and GRS_901_DBP
PPM012857 PSS009576|
South Asian Ancestry|
8,827 individuals
 PGP000283 |
Evangelou E et al. Nat Genet (2018)
 Reported Trait: Pulse pressure β: 1.09 [0.8, 1.39] — — — *Note performance is based on the average between GRS901_SBP and GRS_901_DBP
PPM012858 PSS009576|
South Asian Ancestry|
8,827 individuals
 PGP000283 |
Evangelou E et al. Nat Genet (2018)
 Reported Trait: Hypertension OR: 1.3 [1.24, 1.36] — — — *Note performance is based on the average between GRS901_SBP and GRS_901_DBP
PPM013004 PSS009643|
Ancestry Not Reported|
6,335 individuals
 PGP000317 |
Parcha V et al. Hypertension (2022)
|Ext.		 Reported Trait: Systolic blood pressure β: 1.93 — — PGS002257, age, age^2, sex, BMI, randomization arm, history of CVD event, serum creatinine, fasting blood glucose, LDL levels, 10 genetic PCs *NOTE*: PGS is calculated as an average of PGS002257 and PGS002258
PPM013005 PSS009643|
Ancestry Not Reported|
6,335 individuals
 PGP000317 |
Parcha V et al. Hypertension (2022)
|Ext.		 Reported Trait: Diastolic blood pressure β: 0.65 — — PGS002257, age, age^2, sex, BMI, randomization arm, history of CVD event, serum creatinine, fasting blood glucose, LDL levels, 10 genetic PCs *NOTE*: PGS is calculated as an average of PGS002257 and PGS002258
PPM013006 PSS009643|
Ancestry Not Reported|
6,335 individuals
 PGP000317 |
Parcha V et al. Hypertension (2022)
|Ext.		 Reported Trait: Adverse cardiovascular events HR: 1.12 [1.02, 1.23] — — PGS002257 *NOTE*: PGS is calculated as an average of PGS002257 and PGS002258
PPM015499 PSS009963|
European Ancestry|
33,770 individuals
 PGP000376 |
Åberg F et al. Sci Rep (2022)
|Ext.		 Reported Trait: Liver-related outcome HR: 1.12 [1.01, 1.25] — — Age, sex, body mass index, waist circumference, weekly alcohol use, fraction of alcohol use as wine, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, diabetes, exercise habits, smoking status (current, former, never smoker) and baseline cardiovascular disease —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009643 Corrected for baseline antihypertensive use — 6,335 individuals,
62.7 % Male samples
 Median = 62.1 years
Sd = [57.8, 67.1] years		 Not reported 30.4% non-White individuals ACCORD —
PSS009574 — — 14,004 individuals — European — Airwave —
PSS009575 — — 6,970 individuals — African unspecified — UKB —
PSS009576 — — 8,827 individuals — South Asian — UKB —
PSS009963 — Median = 12.9 years 33,770 individuals,
46.5 % Male samples
 Mean = 49.6 years European
(Finnish)		 Finland FINRISK, Health2000 —