Predicted Trait | |
Reported Trait | Coronary artery disease |
Mapped Trait(s) | coronary artery disease (EFO_0001645) |
Additional Trait Information | Integrating nine optimal trait-specific PRSs (CAD, stroke, BP, T2D, TC, LDL-C, TG, HDL-C and BMI) |
Score Construction | |
PGS Name | metaPRS_CAD |
Development Method | |
Name | metaPRS (elasticnet) |
Parameters | 9 component PRS |
Variants | |
Original Genome Build | GRCh37 |
Number of Variants | 540 |
Effect Weight Type | metaPRS |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000289 |
Citation (link to publication) | Lu X et al. Eur Heart J (2022) |
Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) |
---|---|---|---|
GWAS Catalog: GCST010867 |
[
|
East Asian (Japanese) |
BBJ |
19106391, 22531126 |
[
|
East Asian (Chinese) |
Other |
Europe PMC: 26690388 |
[
|
East Asian (Chinese) |
Other, PUUMA |
GWAS Catalog: GCST005172 Europe PMC: 29263402 |
6,942 individuals | East Asian | SCES, SCHS, SIMES, SP2 |
GWAS Catalog: GCST005172 Europe PMC: 29263402 |
2,603 individuals | South East Asian | SCES, SCHS, SIMES, SP2 |
GWAS Catalog: GCST001260 |
[
|
East Asian (Japanese) |
CAGE |
GWAS Catalog: GCST005978 Europe PMC: 29403010 |
136,615 individuals | East Asian | BBJ |
GWAS Catalog: GCST007847 Europe PMC: 30718926 |
191,764 individuals | East Asian | BBJ |
GWAS Catalog: GCST001351 Europe PMC: 22158537 |
15,000 individuals | East Asian | AGEN |
GWAS Catalog: GCST001351 Europe PMC: 22158537 |
2,034 individuals | South East Asian | AGEN |
GWAS Catalog: GCST001351 Europe PMC: 22158537 |
1,783 individuals | Asian unspecified | AGEN |
GWAS Catalog: GCST004904 |
173,430 individuals | East Asian (Japanese) |
BBJ |
GWAS Catalog: GCST005838 |
[
|
East Asian (Japanese) |
BBJ |
GWAS Catalog: GCST002461 |
[
|
East Asian | AGEN |
Europe PMC: 29083407 |
47,532 individuals | East Asian | NR |
— | [
|
East Asian (Chinese) |
Other |
Europe PMC: 28334899 |
69,414 individuals | East Asian | AGEN |
GWAS Catalog: GCST001587 Europe PMC: 22751097 |
6,534 individuals | East Asian | BAS, CAS |
Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) | Phenotype Definitions & Methods | Age of Study Participants | Participant Follow-up Time | Additional Ancestry Description | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
— | [ ,
64.7 % Male samples |
East Asian | NR | — | Mean = 54.77 years Sd = 7.53 years |
— | — | — |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|
PPM012875 | PSS009589| East Asian Ancestry| 41,271 individuals |
PGP000289 | Lu X et al. Eur Heart J (2022) |
Reported Trait: Incident coronary artery disease | HR: 1.44 [1.36, 1.52] | C-index: 0.615 [0.598, 0.631] | — | — | — |
PPM012876 | PSS009589| East Asian Ancestry| 41,271 individuals |
PGP000289 | Lu X et al. Eur Heart J (2022) |
Reported Trait: Incident coronary artery disease | — | — | Hazard Ratio (HR, highest vs lowest quintile): 2.91 [2.43, 3.49] | — | — |
PPM012877 | PSS009589| East Asian Ancestry| 41,271 individuals |
PGP000289 | Lu X et al. Eur Heart J (2022) |
Reported Trait: Incident coronary artery disease (men) | — | — | Hazard Ratio (HR, highest vs lowest quintile): 3.88 [2.94, 5.13] | sex and first 4 PCs | — |
PPM012878 | PSS009589| East Asian Ancestry| 41,271 individuals |
PGP000289 | Lu X et al. Eur Heart J (2022) |
Reported Trait: Incident coronary artery disease (women) | — | — | Hazard Ratio (HR, highest vs lowest quintile): 2.27 [1.78, 2.9] | sex and first 4 PCs | — |
PPM012879 | PSS009589| East Asian Ancestry| 41,271 individuals |
PGP000289 | Lu X et al. Eur Heart J (2022) |
Reported Trait: Coronary artery disease | — | — | Hazard Ratio (HR, highest vs lowest quintile): 5.66 [3.98, 8.04] | sex, first 4 PCs and CAD family history | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS009589 | — | Mean = 13.0 years | [ ,
42.5 % Male samples |
Mean = 52.3 years Sd = 10.6 years |
East Asian | — | CIMIC, ChinaMUCA-1998, InterASIA | — |