Polygenic Score (PGS) ID: PGS002274

Predicted Trait
Reported Trait LDL cholesterol
Mapped Trait(s) low density lipoprotein cholesterol measurement (EFO_0004611)
Released in PGS Catalog: April 1, 2022
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Score Details

Score Construction
PGS Name LDL-PRS
Development Method
Name Genome-wide significant variants
Parameters p<5E-08
Variants
Original Genome Build NR
Number of Variants 279
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000303
Citation (link to publication) Groenland EH et al. Atherosclerosis (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
237,050 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST009147
Europe PMC: 29083408
 237,050 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012944 PSS009627|
European Ancestry|
4,416 individuals
 PGP000303 |
Groenland EH et al. Atherosclerosis (2022)
 Reported Trait: Low-density lipoprotein cholesterol β: 0.18 [0.15, 0.21] — — Age, sex, the first 5 principal components, BMI, T2DM, smoking, alcohol use, systolic blood pressure, eGFR, triglycerides, lipid-lowering medication —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009627 — — 4,416 individuals,
75.0 % Male samples
 European — UCC-SMART UCC-SMART