Polygenic Score (PGS) ID: PGS002275

Predicted Trait
Reported Trait Systolic blood pressure
Mapped Trait(s) systolic blood pressure (EFO_0006335)
Released in PGS Catalog: April 1, 2022
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Score Details

Score Construction
PGS Name SBP-PRS
Development Method
Name Genome-wide significant variants
Parameters p<5E-08
Variants
Original Genome Build NR
Number of Variants 425
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000303
Citation (link to publication) Groenland EH et al. Atherosclerosis (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 91.2%
African: 6.2%
Hispanic or Latin American: 2%
Additional Asian Ancestries: 0.4%
Additional Diverse Ancestries: 0.2%
1,363,940 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST006628
Europe PMC: 30224653
 757,601 individuals European NR
GWAS Catalog: GCST006228
Europe PMC: 27618448
 120,473 individuals European NR
GWAS Catalog: GCST006228
Europe PMC: 27618448
 21,503 individuals African American or Afro-Caribbean NR
GWAS Catalog: GCST006228
Europe PMC: 27618448
 4,586 individuals Hispanic or Latin American NR
GWAS Catalog: GCST007267
Europe PMC: 30578418
 365,998 individuals European MVP, UKB
GWAS Catalog: GCST007267
Europe PMC: 30578418
 63,490 individuals African unspecified MVP, UKB
GWAS Catalog: GCST007267
Europe PMC: 30578418
 22,802 individuals Hispanic or Latin American MVP, UKB
GWAS Catalog: GCST007267
Europe PMC: 30578418
 4,792 individuals Asian unspecified MVP, UKB
GWAS Catalog: GCST007267
Europe PMC: 30578418
 2,695 individuals Native American MVP, UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012945 PSS009627|
European Ancestry|
4,416 individuals
 PGP000303 |
Groenland EH et al. Atherosclerosis (2022)
 Reported Trait: Systolic blood pressure β: 3.19 [2.6, 3.78] — — Age, sex, the first 5 principal components, BMI, T2DM, smoking, alcohol use, LDL-cholesterol, eGFR, triglycerides, antihypertensive medication —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009627 — — 4,416 individuals,
75.0 % Male samples
 European — UCC-SMART UCC-SMART