Polygenic Score (PGS) ID: PGS002276

Predicted Trait
Reported Trait QTc duration
Mapped Trait(s) QT interval (EFO_0004682)
Additional Trait Information QTc was calculated using the Bazett Formula
Released in PGS Catalog: April 13, 2022
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Score Details

Score Construction
PGS Name QTc_PRS-CS
Development Method
Name PRS-CS
Parameters European 1000G LD data used in PRS-CS
Variants
Original Genome Build GRCh37
Number of Variants 1,110,494
Effect Weight Type posterior effect size
PGS Source
PGS Catalog Publication (PGP) ID PGP000304
Citation (link to publication) Nauffal V et al. Circulation (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
Multi-ancestry (including European): 100%
  • European
  • African
  • Additional Asian Ancestries
  • Additional Diverse Ancestries
  • Not Reported
84,630 individuals (100%)
Score Development/Training
Multi-ancestry (including European): 100%
  • European
  • African
  • Additional Asian Ancestries
  • Additional Diverse Ancestries
  • Not Reported
84,630 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • European
  • African
  • Additional Asian Ancestries
  • Additional Diverse Ancestries
  • Not Reported
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
Europe PMC: 35389749
 84,630 individuals,
48.6 % Male samples
 European, African unspecified, Asian unspecified, Other admixed ancestry, Not reported UKB
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
Europe PMC: 35389749
 84,630 individuals,
48.6 % Male samples
 European, African unspecified, Asian unspecified, Other admixed ancestry, Not reported UKB Bazzet formula QT-corrected interval calculated from automated QT interval obtained from 12-lead or 3-lead electrocardiograms in the UK Biobank Mean = 57.9 years
Sd = 8.8 years		 — Combined analysis of European (93.5%), African (1.9%), Asian (1.8%), Admixed American (0.1%) and Undetermined (2.7%) genetic ancestries —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012946 PSS009628|
Multi-ancestry (including European)|
26,976 individuals
 PGP000304 |
Nauffal V et al. Circulation (2022)
 Reported Trait: QTc — — R²: 0.087 age, sex, beta blocker use, calcium channel blocker use, heart failure, myocardial infarction, first 12 principal components of genetic ancestry (PC1-12) PRS performance was overall similar across the individual genetic ancestries in TOPMed. (European R²: 0.074; African R²:0.077, Admixed American R²:0.148; Amish R²:0.197; Asian R²:0.245; Undetermined Genetic Ancestry R²:0.106)

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009628 Bazzet formula QT-corrected interval calculated from automated QT interval obtained from 12-lead electrocardiograms in TOPMed — 26,976 individuals,
65.4 % Male samples
 Mean = 59.8 years
Sd = 12.5 years		 European, African unspecified, Asian unspecified, Other admixed ancestry, Not reported Combined analysis of European (59.6%), African (18.1%), Asian (2.9%), Admixed American (2.2%), Amish (3.7%) and Undetermined (13.5%) genetic ancestries 9 cohorts
  • ARIC
  • ,BioMe
  • ,CFS
  • ,CHS
  • ,FHS
  • ,JHS
  • ,MESA
  • ,OOA
  • ,WHI
 —