| Predicted Trait | |
| Reported Trait | Supranormal left ventricular ejection fraction |
| Mapped Trait(s) | left ventricular ejection fraction measurement (EFO_0008373) |
| Score Construction | |
| PGS Name | GRS16_snLVEF |
| Development Method | |
| Name | Genome-wide significant variants |
| Parameters | p<5E-08, r2<0.05 |
| Variants | |
| Original Genome Build | GRCh38 |
| Number of Variants | 16 |
| Effect Weight Type | beta |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000307 |
| Citation (link to publication) | Forrest IS et al. Eur J Heart Fail (2022) |
| Ancestry Distribution | |
| Source of Variant Associations (GWAS) | |
| PGS Evaluation | |
| Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) |
|---|---|---|---|
Europe PMC: 35278270 |
[
|
African unspecified, Hispanic or Latin American, European, Asian unspecified, NR | BioMe, UKB |
|
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM012952 | PSS009631| Multi-ancestry (including European)| 486,754 individuals |
PGP000307 | Forrest IS et al. Eur J Heart Fail (2022) |
Reported Trait: All-cause mortality | — | — | HR (top 10% vs bottom 10%): 1.11 [1.04, 1.18] | Age, sex, body mass index (BMI; except for obesity),10 principal components of ancestry | — |
| PPM012954 | PSS009631| Multi-ancestry (including European)| 486,754 individuals |
PGP000307 | Forrest IS et al. Eur J Heart Fail (2022) |
Reported Trait: All-cause mortality (with heart failure) | — | — | HR (top 10% vs bottom 10%): 1.26 [1.05, 1.5] | Age, sex, body mass index (BMI; except for obesity),10 principal components of ancestry | — |
| PPM012956 | PSS009631| Multi-ancestry (including European)| 486,754 individuals |
PGP000307 | Forrest IS et al. Eur J Heart Fail (2022) |
Reported Trait: All-cause mortality (without heart failure) | — | — | HR (top 10% vs bottom 10%): 1.09 [1.02, 1.17] | Age, sex, body mass index (BMI; except for obesity),10 principal components of ancestry | — |
| PPM012957 | PSS009631| Multi-ancestry (including European)| 486,754 individuals |
PGP000307 | Forrest IS et al. Eur J Heart Fail (2022) |
Reported Trait: Heart failure diagnosis | OR: 0.97 [0.95, 0.99] | — | — | Age, sex, body mass index,10 principal components of ancestry | — |
| PPM012958 | PSS009631| Multi-ancestry (including European)| 486,754 individuals |
PGP000307 | Forrest IS et al. Eur J Heart Fail (2022) |
Reported Trait: Brain natriuretic peptide level | — | — | Median (top 10% vs bottom 10%): 146.0 [79, 228] pg/ml | — | — |
| PPM012959 | PSS009631| Multi-ancestry (including European)| 486,754 individuals |
PGP000307 | Forrest IS et al. Eur J Heart Fail (2022) |
Reported Trait: Prevalence of dyspnoea | — | — | OR (top 10% vs bottom 10%): 1.17 [1.01, 1.37] | — | — |
| PPM012960 | PSS009631| Multi-ancestry (including European)| 486,754 individuals |
PGP000307 | Forrest IS et al. Eur J Heart Fail (2022) |
Reported Trait: Exertional dyspnoea | — | — | OR (top 10% vs bottom 10%): 1.39 [1.12, 1.74] | — | — |
| PPM012961 | PSS009631| Multi-ancestry (including European)| 486,754 individuals |
PGP000307 | Forrest IS et al. Eur J Heart Fail (2022) |
Reported Trait: Peperipheral oedema | — | — | OR (top 10% vs bottom 10%): 1.07 [1.01, 1.13] | — | — |
| PPM012962 | PSS009631| Multi-ancestry (including European)| 486,754 individuals |
PGP000307 | Forrest IS et al. Eur J Heart Fail (2022) |
Reported Trait: Medication for heart failure (loop diuretics) | — | — | OR (top 10% vs bottom 10%): 1.03 [1.01, 1.05] | — | — |
| PPM012963 | PSS009631| Multi-ancestry (including European)| 486,754 individuals |
PGP000307 | Forrest IS et al. Eur J Heart Fail (2022) |
Reported Trait: Medication for heart failure (mineralocorticoid receptor antagonists) | — | — | OR (top 10% vs bottom 10%): 1.04 [1.01, 1.09] | — | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS009631 | ICD-10 diagnosis code for hypertensive heart disease with heart failure, hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or heart failure (I11.0, I13.0, I13.2, I50) in BioMe biobank and ICD-10 diagnosis code for hypertensive heart disease with heart failure, hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or heart failure (I11.0, I13.0, I13.2, I50) in UKB; ICD-10 diagnosis code for exertional dyspnea (R06.09) and/or physician-documented exertional dyspnea in the problem list; ICD-10 diagnosis code for peripheral edema (R60) and/or physician-documented peripheral edema in the problem list (e.g., “ankle swelling”, “lower extremity swelling”); (e.g., “shortness of breath”, “difficulty breathing”; and “on exertion”, “when exercising”); ICD-10 diagnosis code for dyspnea (R06.0) and/or physician-documented dyspnea in the problem list (e.g., “shortness of breath”, “trouble breathing”) | — | 486,754 individuals, 46.0 % Male samples |
Median = 58.0 years | African unspecified, Hispanic or Latin American, European, Asian unspecified, NR | African, Hispanic/Latino, European, Asian, Other ancestry | BioMe, UKB | — |