Polygenic Score (PGS) ID: PGS002289

Predicted Trait
Reported Trait Late-onset Alzheimer's disease
Mapped Trait(s) late-onset Alzheimer's disease (EFO_1001870)
Released in PGS Catalog: May 18, 2022
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Score Details

Score Construction
PGS Name GRS23_AD
Development Method
Name GWAS-significant variants (including APOE)
Parameters NR
Variants
Original Genome Build NR
Number of Variants 23
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000316
Citation (link to publication) Zimmerman SC et al. JAMA Netw Open (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
55,134 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST002245
Europe PMC: 24162737
 55,134 individuals European 19 cohorts
  • ACT
  • ,ADC
  • ,ADNI
  • ,AGES
  • ,CHS
  • ,EADI
  • ,FHS
  • ,GERAD
  • ,GSK
  • ,LOAD
  • ,MAYO
  • ,MIRAGE
  • ,OHSU
  • ,ROSMAP
  • ,RS
  • ,TGEN
  • ,UMVUMSS
  • ,UPITT
  • ,WASHU

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012991 PSS009642|
European Ancestry|
497,087 individuals
 PGP000316 |
Zimmerman SC et al. JAMA Netw Open (2022)
 Reported Trait: Pairs matching (short-term memory and attention) time to complete in person round 1 x age interaction — — Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 5.3 — —
PPM012992 PSS009642|
European Ancestry|
497,087 individuals
 PGP000316 |
Zimmerman SC et al. JAMA Netw Open (2022)
 Reported Trait: Pairs matching (short-term memory and attention) no. of incorrect in person round 1 x age interaction — — Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 4.4 — —
PPM012993 PSS009642|
European Ancestry|
497,087 individuals
 PGP000316 |
Zimmerman SC et al. JAMA Netw Open (2022)
 Reported Trait: Pairs matching (short-term memory and attention) time to complete online round 1 x age interaction — — Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 3.5 — —
PPM012994 PSS009642|
European Ancestry|
497,087 individuals
 PGP000316 |
Zimmerman SC et al. JAMA Netw Open (2022)
 Reported Trait: Pairs matching (short-term memory and attention) time to complete in person round 2 x age interaction — — Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 2.5 — —
PPM012995 PSS009642|
European Ancestry|
497,087 individuals
 PGP000316 |
Zimmerman SC et al. JAMA Netw Open (2022)
 Reported Trait: Numeric memory (short-term memory and attention) no. of correct online x age interaction — — Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 8.8 — —
PPM012996 PSS009642|
European Ancestry|
497,087 individuals
 PGP000316 |
Zimmerman SC et al. JAMA Netw Open (2022)
 Reported Trait: Symbol digit substitution (processing speed) no. of correct in person x age interaction — — Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 5.8 — —
PPM012997 PSS009642|
European Ancestry|
497,087 individuals
 PGP000316 |
Zimmerman SC et al. JAMA Netw Open (2022)
 Reported Trait: Symbol digit substitution (processing speed) no. attempted in person x age interaction — — Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 5.7 — —
PPM012998 PSS009642|
European Ancestry|
497,087 individuals
 PGP000316 |
Zimmerman SC et al. JAMA Netw Open (2022)
 Reported Trait: Symbol digit substitution (processing speed) time to complete 10 substitutions online x age interaction — — Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 4.5 — —
PPM012999 PSS009642|
European Ancestry|
497,087 individuals
 PGP000316 |
Zimmerman SC et al. JAMA Netw Open (2022)
 Reported Trait: Symbol digit substitution (processing speed) no. of correct online x age interaction — — Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 2.4 — —
PPM013000 PSS009642|
European Ancestry|
497,087 individuals
 PGP000316 |
Zimmerman SC et al. JAMA Netw Open (2022)
 Reported Trait: Symbol digit substitution (processing speed) no. attempted online x age interaction — — Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 2.0 — —
PPM012988 PSS009642|
European Ancestry|
497,087 individuals
 PGP000316 |
Zimmerman SC et al. JAMA Netw Open (2022)
 Reported Trait: Pairs matching (short-term memory and attention) no. of correct online round 1 x age interaction — — Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 11.5 — —
PPM012989 PSS009642|
European Ancestry|
497,087 individuals
 PGP000316 |
Zimmerman SC et al. JAMA Netw Open (2022)
 Reported Trait: Pairs matching (short-term memory and attention) no. of correct in person round 1 x age interaction — — Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 7.9 — —
PPM012990 PSS009642|
European Ancestry|
497,087 individuals
 PGP000316 |
Zimmerman SC et al. JAMA Netw Open (2022)
 Reported Trait: Pairs matching (short-term memory and attention) no. of correct in person round 2 x age interaction — — Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 9.4 — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009642 G30.1 Alzheimer’s disease with late onset — 497,087 individuals,
45.9 % Male samples
 Mean = 57.1 years
Sd = 7.9 years		 European — UKB —