Polygenic Score (PGS) ID: PGS002290

Predicted Trait
Reported Trait Uric acid level
Mapped Trait(s) uric acid measurement (EFO_0004761)
Released in PGS Catalog: May 18, 2022
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Score Details

Score Construction
PGS Name GRS10_PUA
Development Method
Name Genome-wide significant variants
Parameters p<0.05, r2<0.100, SNP not associated with other traits
Variants
Original Genome Build hg19
Number of Variants 10
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000318
Citation (link to publication) Gurung RL et al. J Clin Endocrinol Metab (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
East Asian: 100%
234,754 individuals (100%)
PGS Evaluation
East Asian: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST008972
Europe PMC: 31578528
 125,725 individuals East Asian NR
GWAS Catalog: GCST005983
Europe PMC: 29403010
 109,029 individuals East Asian NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM013007 PSS009644|
East Asian Ancestry|
1,146 individuals
 PGP000318 |
Gurung RL et al. J Clin Endocrinol Metab (2022)
 Reported Trait: Plasma uric acid level β: 0.142 (0.025) — — Age, sex —
PPM013008 PSS009644|
East Asian Ancestry|
1,146 individuals
 PGP000318 |
Gurung RL et al. J Clin Endocrinol Metab (2022)
 Reported Trait: Rapid decline in kidney function OR: 1.12 [1.01, 1.24] — — Age, sex, MI, HbA1c, diabetes duration, SBP, eGFR, ln uACR, RAS antagonist and Insulin usage (yes/no) —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009644 — —
[
  • 160 cases
  • , 986 controls
]
 — East Asian
(Chinese)		 — DN, SMART2D —