Polygenic Score (PGS) ID: PGS002293

Predicted Trait
Reported Trait Psoriasis
Mapped Trait(s) psoriasis (EFO_0000676)
Released in PGS Catalog: May 18, 2022
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Score Details

Score Construction
PGS Name PRS62_psoriasis
Development Method
Name Genome-wide significant variants
Parameters SNPs available in the UK Biobank
Variants
Original Genome Build NR
Number of Variants 62
Effect Weight Type ln(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000323
Citation (link to publication) Shen M et al. J Am Acad Dermatol (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
287,323 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST004346
Europe PMC: 28537254
 287,323 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM013020 PSS009651|
European Ancestry|
345,672 individuals
 PGP000323 |
Shen M et al. J Am Acad Dermatol (2022)
 Reported Trait: Incident psoriasis HR: 4.625 [2.92, 7.348] — Odds Ratio (OR, poor lifestyle and high genetic risk): 4.625 [2.92, 7.348]
Population-attributable fraction of genetic risk: 0.13 [0.032, 0.218]		 Age, sex, education, Townsend Index, and region, relatedness, number of alleles included in the polygenic risk score, and first 20 principal components of ancestry —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009651 — Median = 10.88 years 345,672 individuals,
48.0 % Male samples
 Mean = 56.53 years
Sd = 8.06 years		 European — UKB —