Polygenic Score (PGS) ID: PGS002295

Predicted Trait
Reported Trait Insulin growth-like factor-1 level
Mapped Trait(s) insulin like growth factor measurement (EFO_0004628)
Released in PGS Catalog: May 18, 2022
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Score Details

Score Construction
PGS Name GRS413_IGF-1
Development Method
Name Genome-wide significant variants
Parameters NR
Variants
Original Genome Build NR
Number of Variants 413
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000325
Citation (link to publication) Tsai CW et al. American Journal of Cancer Research (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
Not Reported: 61.1%
European: 37.6%
South Asian: 0.7%
African: 0.6%
988,351 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
Europe PMC: 31884074
 397,380 individuals Not reported UKB
Europe PMC: 32169310
 206,263 individuals,
0.0 % Male samples
 Not reported UKB
Europe PMC: 27329260
 30,884 individuals,
47.0 % Male samples
 European NR
GWAS Catalog: GCST90019511
Europe PMC: 33462484
 340,567 individuals European NR
GWAS Catalog: GCST90019511
Europe PMC: 33462484
 5,974 individuals African unspecified NR
GWAS Catalog: GCST90019511
Europe PMC: 33462484
 7,283 individuals South Asian NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM013023 PSS009653|
European Ancestry|
1,010 individuals
 PGP000325 |
Tsai CW et al. American Journal of Cancer Research (2022)
 Reported Trait: Recurrence in renal cell carcinoma HR: 0.63 [0.42, 0.93] — Hazard Ratio (HR, above vs. below median): 0.63 [0.42, 0.93]
Odds Ratio (OR, above vs. below 75th percentile GRS): 0.73 [0.55, 0.96]		 Age, gender, smoking status, BMI, histology, stage, grade, and treatment —
PPM013024 PSS009653|
European Ancestry|
1,010 individuals
 PGP000325 |
Tsai CW et al. American Journal of Cancer Research (2022)
 Reported Trait: Survival in renal cell carcinoma HR: 0.65 [0.44, 0.95] — Hazard Ratio (HR, above vs. below median): 0.65 [0.44, 0.95]
Odds Ratio (OR, above vs. below 75th percentile GRS): 0.66 [0.5, 0.87]		 Age, gender, smoking status, BMI, histology, stage, grade, and treatment —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009653 — — 1,010 individuals — European — NR —