Polygenic Score (PGS) ID: PGS002328

Predicted Trait
Reported Trait Glucose
Mapped Trait(s) glucose measurement (EFO_0004468)
Released in PGS Catalog: June 9, 2022
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Score Details

Score Construction
PGS Name biochemistry_Glucose.BOLT-LMM
Development Method
Name BOLT-LMM
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 1,109,311
Effect Weight Type BETA
PGS Source
PGS Catalog Publication (PGP) ID PGP000332
Citation (link to publication) Weissbrod O et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
291,275 individuals (100%)
PGS Evaluation
African: 25%
East Asian: 25%
European: 25%
South Asian: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
291,275 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM013093 PSS009755|
African Ancestry|
5,505 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Glucose Incremental R2 (full model vs. covariates alone): 0.0089 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013142 PSS009756|
East Asian Ancestry|
794 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Glucose Incremental R2 (full model vs. covariates alone): 0.0154 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013191 PSS009757|
European Ancestry|
37,281 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Glucose Incremental R2 (full model vs. covariates alone): 0.0298 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013240 PSS009758|
South Asian Ancestry|
6,744 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Glucose Incremental R2 (full model vs. covariates alone): 0.0219 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009756 794 individuals East Asian UKB
PSS009757 37,281 individuals European Non-British European UKB
PSS009758 6,744 individuals South Asian UKB
PSS009755 5,505 individuals African unspecified UKB