Polygenic Score (PGS) ID: PGS002329

Predicted Trait
Reported Trait HDL cholesterol
Mapped Trait(s) high density lipoprotein cholesterol measurement (EFO_0004612)
Released in PGS Catalog: June 9, 2022
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Score Details

Score Construction
PGS Name biochemistry_HDLcholesterol.BOLT-LMM
Development Method
Name BOLT-LMM
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 1,109,311
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000332
Citation (link to publication) Weissbrod O et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
294,075 individuals (100%)
PGS Evaluation
African: 25%
East Asian: 25%
European: 25%
South Asian: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
— 294,075 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM013094 PSS009759|
African Ancestry|
5,619 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: HDL Cholesterol — — Incremental R2 (full model vs. covariates alone): 0.0518 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013143 PSS009760|
East Asian Ancestry|
797 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: HDL Cholesterol — — Incremental R2 (full model vs. covariates alone): 0.0918 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013192 PSS009761|
European Ancestry|
37,633 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: HDL Cholesterol — — Incremental R2 (full model vs. covariates alone): 0.1578 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013241 PSS009762|
South Asian Ancestry|
6,980 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: HDL Cholesterol — — Incremental R2 (full model vs. covariates alone): 0.1256 age, sex, age*sex, assessment center, genotyping array, 10 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009759 — — 5,619 individuals — African unspecified — UKB —
PSS009760 — — 797 individuals — East Asian — UKB —
PSS009761 — — 37,633 individuals — European Non-British European UKB —
PSS009762 — — 6,980 individuals — South Asian — UKB —