Polygenic Score (PGS) ID: PGS002343

Predicted Trait
Reported Trait Platelet count
Mapped Trait(s) platelet count (EFO_0004309)
Released in PGS Catalog: June 9, 2022
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Score Details

Score Construction
PGS Name blood_PLATELET_COUNT.BOLT-LMM
Development Method
Name BOLT-LMM
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 1,109,311
Effect Weight Type BETA
PGS Source
PGS Catalog Publication (PGP) ID PGP000332
Citation (link to publication) Weissbrod O et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
326,621 individuals (100%)
PGS Evaluation
African: 25%
East Asian: 25%
European: 25%
South Asian: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
326,621 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM013108 PSS009815|
African Ancestry|
6,143 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Platelet count Incremental R2 (full model vs. covariates alone): 0.0682 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013157 PSS009816|
East Asian Ancestry|
895 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Platelet count Incremental R2 (full model vs. covariates alone): 0.0998 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013206 PSS009817|
European Ancestry|
42,007 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Platelet count Incremental R2 (full model vs. covariates alone): 0.2489 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013255 PSS009818|
South Asian Ancestry|
7,730 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Platelet count Incremental R2 (full model vs. covariates alone): 0.1747 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009815 6,143 individuals African unspecified UKB
PSS009816 895 individuals East Asian UKB
PSS009817 42,007 individuals European Non-British European UKB
PSS009818 7,730 individuals South Asian UKB