Polygenic Score (PGS) ID: PGS002358

Predicted Trait
Reported Trait Asthma
Mapped Trait(s) asthma (MONDO_0004979)
Released in PGS Catalog: June 9, 2022
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Score Details

Score Construction
PGS Name disease_ASTHMA_DIAGNOSED.BOLT-LMM-BBJ
Development Method
Name BOLT-LMM-BBJ
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 920,922
Effect Weight Type BETA
PGS Source
PGS Catalog Publication (PGP) ID PGP000332
Citation (link to publication) Weissbrod O et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
East Asian: 100%
124,000 individuals (100%)
PGS Evaluation
African: 25%
East Asian: 25%
European: 25%
South Asian: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
124,000 individuals East Asian BBJ

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM013270 PSS009687|
African Ancestry|
6,423 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Asthma Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013293 PSS009688|
East Asian Ancestry|
905 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Asthma Incremental R2 (full model vs. covariates alone): 0.0016 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013316 PSS009689|
European Ancestry|
43,398 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Asthma Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013339 PSS009690|
South Asian Ancestry|
7,942 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Asthma Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009687 6,423 individuals African unspecified UKB
PSS009688 905 individuals East Asian UKB
PSS009689 43,398 individuals European Non-British European UKB
PSS009690 7,942 individuals South Asian UKB