Polygenic Score (PGS) ID: PGS002365

Predicted Trait
Reported Trait Glucose
Mapped Trait(s) glucose measurement (EFO_0004468)
Released in PGS Catalog: June 9, 2022
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Score Details

Score Construction
PGS Name biochemistry_Glucose.BOLT-LMM-BBJ
Development Method
Name BOLT-LMM-BBJ
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 920,926
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000332
Citation (link to publication) Weissbrod O et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
East Asian: 100%
124,000 individuals (100%)
PGS Evaluation
African: 25%
East Asian: 25%
European: 25%
South Asian: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
— 124,000 individuals East Asian BBJ

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM013277 PSS009755|
African Ancestry|
5,505 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Glucose — — Incremental R2 (full model vs. covariates alone): 0.0012 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013300 PSS009756|
East Asian Ancestry|
794 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Glucose — — Incremental R2 (full model vs. covariates alone): 0.0068 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013323 PSS009757|
European Ancestry|
37,281 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Glucose — — Incremental R2 (full model vs. covariates alone): 0.001 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013346 PSS009758|
South Asian Ancestry|
6,744 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Glucose — — Incremental R2 (full model vs. covariates alone): 0.0025 age, sex, age*sex, assessment center, genotyping array, 10 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009756 — — 794 individuals — East Asian — UKB —
PSS009757 — — 37,281 individuals — European Non-British European UKB —
PSS009758 — — 6,744 individuals — South Asian — UKB —
PSS009755 — — 5,505 individuals — African unspecified — UKB —