Polygenic Score (PGS) ID: PGS002367

Predicted Trait
Reported Trait HbA1c
Mapped Trait(s) HbA1c measurement (EFO_0004541)
Released in PGS Catalog: June 9, 2022
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Score Details

Score Construction
PGS Name biochemistry_HbA1c.BOLT-LMM-BBJ
Development Method
Name BOLT-LMM-BBJ
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 920,924
Effect Weight Type BETA
PGS Source
PGS Catalog Publication (PGP) ID PGP000332
Citation (link to publication) Weissbrod O et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
East Asian: 100%
124,000 individuals (100%)
PGS Evaluation
African: 25%
East Asian: 25%
European: 25%
South Asian: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
124,000 individuals East Asian BBJ

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM013279 PSS009767|
African Ancestry|
4,803 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: HbA1c Incremental R2 (full model vs. covariates alone): 0.0001 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013302 PSS009768|
East Asian Ancestry|
841 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: HbA1c Incremental R2 (full model vs. covariates alone): 0.0153 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013325 PSS009769|
European Ancestry|
38,991 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: HbA1c Incremental R2 (full model vs. covariates alone): 0.0014 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013348 PSS009770|
South Asian Ancestry|
6,861 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: HbA1c Incremental R2 (full model vs. covariates alone): 0.0018 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009767 4,803 individuals African unspecified UKB
PSS009768 841 individuals East Asian UKB
PSS009769 38,991 individuals European Non-British European UKB
PSS009770 6,861 individuals South Asian UKB